ArticleMedical oncology (Northwood, London, England)2014
High percentage of α1-globulin in serum protein is associated with unfavorable prognosis in non-small cell lung cancer.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Multiparameter diagnostic model using S100A9, CCL5 and blood biomarkers for nasopharyngeal carcinoma.Scientific reports · 2025Article
- A Simple Model Established by Blood Markers Predicting Overall Survival After Radical Resection of Pancreatic Ductal Adenocarcinoma.Frontiers in oncology · 2020Article
- Sodium to globulin ratio as a prognostic factor for patients with advanced gastric cancer.Journal of Cancer · 2020Article
- Prealbumin-to-Globulin Ratio Can Predict the Chemotherapy Outcomes and Prognosis of Patients with Gastric Cancer Receiving First-Line Chemotherapy.Journal of immunology research · 2020Article
- Prognostic value of preoperative albumin to globulin ratio in elderly patients with rectal cancer.Medicine · 2019Article
- Serum Alpha1-Globulin as a Novel Prognostic Factor in Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors.Targeted oncology · 2019Article
- Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters.Oncology letters · 2019Article
- An inflammation-related nomogram for predicting the survival of patients with non-small cell lung cancer after pulmonary lobectomy.BMC cancer · 2018Article
- Prognostic Values of Systemic Inflammation Response (SIR) Parameters in Resectable Cervical Cancer.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of the percentage composition of serum protein in patients undergoing lung resections for non-small cell lung cancer (NSCLC) with overall survival and recurrence-free survival has never been investigated. Patients were selected consecutively from the database of the Bio-Bank of Shandong Provincial Hospital. We retrospectively examined the impact of preoperative percentage composition of serum protein detected by serum protein electrophoresis on survival. Furthermore, we investigated the relationships between the potential prognostic biomarkers and clinicopathological factors. A total of 390 patients were evaluated. The higher percentage of α1-globulin in serum protein was significantly associated with histology type (p<0.001), worse tumor status (p<0.001) and higher pathological stage (p=0.004). The α1-globulin percentage composition was an independent prognostic factor for overall survival (hazard ratio 1.52, 95% CI 1.04-2.23, p=0.03). High percentage of α1-globulin in serum protein was also related to short recurrence survival (hazard ratio 1.56, 95% CI 1.14-2.13, p=0.005). Our results showed that the percentage of α1-globulin in serum protein may be an independent prognostic factor in NSCLC.
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