ArticleFish physiology and biochemistry2015
Hematological changes and cytogenotoxicity in the tilapia Oreochromis niloticus caused by sub-chronic exposures to mercury and selenium.
Article in Fish physiology and biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Xenobiotic exposure may confound traditional stress biomarkers: evaluating perfluoropentanoic acid and cadmium effects on largemouth bass (Conservation physiology · 2026Article
- Hematological Parameters and Mercury Exposure in Children Living Along Gold-Mining-Impacted Rivers in the Mojana Region, Colombia.Biological trace element research · 2025Article
- Genotoxic and Hematological Effects Associated with Chronic Dietary Mercury Toxicity in Juvenile TilapiaACS omega · 2025Article
- Partial immune responses in Sichuan bream (Frontiers in immunology · 2023Article
- Mercury chloride toxicity in juveniles Prochilodus argenteus a species from southeastern Brazil.Environmental science and pollution research international · 2022Article
- Exposure to effluent from pharmaceutical industry induced cytogenotoxicity, hematological and histopathological alterations inEXCLI journal · 2019Article
- Hair Mercury Level is Associated with Anemia and Micronutrient Status in Children Living Near Artisanal and Small-Scale Gold Mining in the Peruvian Amazon.The American journal of tropical medicine and hygiene · 2017Article
- Sublethal effects of pulp and paper mill effluent on two commonly cultured carps: a SEM- and EDS-based hematological biomarker analysis.Fish physiology and biochemistry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish bioassays are valuable tools that can be used to elucidate the toxicological potential of numerous substances that are present in the aquatic environment. In this study, we assessed the antagonistic action of selenium (Se) against the toxicity of mercury (Hg) in fish (Oreochromis niloticus). Six experimental groups with six fish each were defined as follows: (1) control, (2) mercury (HgCl(2)), (3) sodium selenite (Na(2)Se(4)O(3)), (4) sodium selenate (Na(2)Se(6)O(4)), (5) mercury + sodium selenite (HgCl(2) + Na(2)Se(4)O(3)), and (6) mercury + sodium selenate (HgCl(2) + Na(2)Se(6)O(4)). Hematological parameters [red blood cells (RBC), white blood cells (WBC), and erythroblasts (ERB)] in combination with cytogenotoxicity biomarkers [nuclear abnormalities (NAs) and micronuclei (MN)] were examined after three, seven, ten, and fourteen days. After 7 days of exposure, cytogenotoxic effects and increased erythroblasts caused by mercury, leukocytosis triggered by mercury + sodium selenite, leukopenia associated with sodium selenate, and anemia triggered by mercury + sodium selenate were observed. Positive correlations that were independent of time were observed between WBC and RBC, ERB and MN, and NA and MN. The results suggest that short-term exposure to chemical contaminants elicited changes in blood parameters and produced cytogenotoxic effects. Moreover, NAs are the primary manifestations of MN formation and should be included in a class characterized as NA only. Lastly, the staining techniques used can be applied to both hematological characterization and the measurement of cytogenotoxicity biomarkers.
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