ArticleJournal of cancer research and clinical oncology2015
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Article in Journal of cancer research and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
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- Proteomics in pancreatic cancer.Biomarker research · 2025Review
- Identification of disease phenotypes in acetylcholine receptor-antibody myasthenia gravis using proteomics-based consensus clustering.EBioMedicine · 2024Article
- Potentially functional variants ofFrontiers in immunology · 2024Article
- Cyclin O promotes lung cancer progression and cetuximab resistance via cell cycle regulation andJournal of thoracic disease · 2023Article
- Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population.Pathology oncology research : POR · 2022Article
- An integrated DNA and RNA variant detector identifies a highly conserved three base exon in theRNA biology · 2021Article
- The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer.Cancers · 2019Review
- Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead.Journal of the American Society for Mass Spectrometry · 2019Article
- Omics Approaches in Pancreatic Adenocarcinoma.Cancers · 2019Review
- Quantitative proteomics identifies brain acid soluble protein 1 (BASP1) as a prognostic biomarker candidate in pancreatic cancer tissue.EBioMedicine · 2019Article
- Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.Molecular medicine reports · 2019Article
- Emerging Roles of the TRIM E3 Ubiquitin Ligases MID1 and MID2 in Cytokinesis.Frontiers in physiology · 2019Review
- KIF5A Promotes Bladder Cancer ProliferationDisease markers · 2019Article
- Sperm-Associated Antigen 5 Expression Is Increased in Hepatocellular Carcinoma and Indicates Poor Prognosis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma.Molecular cancer · 2018Article
- Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis.Cancer medicine · 2017Article
- Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.International journal of biological sciences · 2017Review
- Overexpression and biological function of MEF2D in human pancreatic cancer.American journal of translational research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with early stage pancreatic cancer.
methodsWe analyzed serum samples from patients with resectable pancreatic cancer, benign pancreatic disease, and healthy controls. The SYNAPT G2-Si platform was used in a data-independent manner coupled with ion mobility. The dilution of the samples with yeast alcohol dehydrogenase tryptic digest of known concentration allowed the estimated amounts of each identified protein to be calculated (Silva et al. in Anal Chem 77:2187-2200, 2005; Silva et al. in Mol Cell Proteomics 5:144-156, 2006). A global protein expression comparison of the three study groups was made using label-free quantification and bioinformatic analyses.
resultsTwo-way unsupervised hierarchical clustering revealed 134 proteins that successfully classified pancreatic cancer patients from the controls, and identified 40 proteins that showed a significant up-regulation in the pancreatic cancer group. This discrimination reliability was further confirmed by principal component analysis. The differentially expressed candidates were aligned with protein network analyses and linked to biological pathways related to pancreatic tumorigenesis. Pancreatic disease link associations could be made for BAZ2A, CDK13, DAPK1, DST, EXOSC3, INHBE, KAT2B, KIF20B, SMC1B, and SPAG5, by pathway network linkages to p53, the most frequently altered tumor suppressor in pancreatic cancer.
conclusionThese pancreatic cancer study candidates may provide new avenues of research for a noninvasive blood-based diagnosis for pancreatic tumor stratification.
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