Evidence map›Paper›PMID 25216511›Full record

ArticleJournal of dental research2014

Spatiotemporally controlled microchannels of periodontal mimic scaffolds.

C H Park, K H Kim, H F Rios, Y M Lee, W V Giannobile, Y J Seol

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Advanced biomaterials for periodontal tissue regeneration.Genesis (New York, N.Y. : 2000) · 2022
    Review
  11. Article
  12. Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives.Journal of dental research, dental clinics, dental prospects · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Challenges of Engineering Biomimetic Dental and Paradental Tissues.Tissue engineering and regenerative medicine · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C H ParkDepartment of Periodontology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea.
K H KimDepartment of Periodontology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
H F RiosDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Y M LeeDepartment of Periodontology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
W V GiannobileDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA.
Y J SeolDepartment of Periodontology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea yjseol@snu.ac.kr.

Funding

GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUESR01DE013397 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIANNOBILE, WILLIAM V · 2000 to 2014
$4.0M
NIDCR NIH HHS R01 DE013397
6 · The paper itself

Abstract

Physiologic bioengineering of the oral, dental, and craniofacial complex requires optimized geometric organizations of fibrous connective tissues. A computer-designed, fiber-guiding scaffold has been developed to promote tooth-supporting periodontal tissue regeneration and functional restoration despite limited printing resolution for the manufacture of submicron-scaled features. Here, we demonstrate the use of directional freeze-casting techniques to control pore directional angulations and create mimicked topographies to alveolar crest, horizontal, oblique, and apical fibers of natural periodontal ligaments. For the differing anatomic positions, the gelatin displayed varying patterns of ice growth, determined via internal pore architectures. Regardless of the freezing coordinates, the longitudinal pore arrangements resulted in submicron-scaled diameters (~50 µm), along with corresponding high biomaterial porosity (~90%). Furthermore, the horizontal + coronal ([Formula: see text]) freezing orientation facilitated the creation of similar structures to major fibers in the periodontal ligament interface. This periodontal tissue-mimicking microenvironment is a potential tissue platform for the generation of naturally oriented ligamentous tissues consistent with periodontal ligament neogenesis.

Indexed as

AnimalsBiocompatible MaterialsBioengineeringCell Culture TechniquesCell ProliferationCell SurvivalConnective TissueDogsFreeze DryingFreezingGelatinGuided Tissue Regeneration, PeriodontalHumansIceImaging, Three-DimensionalMicroscopy, Electron, ScanningBiocompatible MaterialsGelatinIcebioengineeringbiomaterialsfreeze castingperiodontal ligamentregenerative medicinetissue engineering

Identifiers

PMID25216511
PMCPMC4237636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.