ArticleJournal of cellular and molecular medicine2014
Meniscus maturation in the swine model: changes occurring along with anterior to posterior and medial to lateral aspect during growth.
Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Degradation of Proteoglycans and Collagen in Equine Meniscal Tissues.International journal of molecular sciences · 2024Article
- Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue.PloS one · 2024Article
- Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.Osteoarthritis and cartilage open · 2023Article
- Meniscus heterogeneity and 3D-printed strategies for engineering anisotropic meniscus.International journal of bioprinting · 2023Article
- Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells.Biomedicines · 2022Article
- Meniscus Matrix Structural and Biomechanical Evaluation: Age-Dependent Properties in a Swine Model.Bioengineering (Basel, Switzerland) · 2022Article
- A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading.Frontiers in bioengineering and biotechnology · 2022Article
- Testing Hypoxia in Pig Meniscal Culture: Biological Role of the Vascular-Related Factors in the Differentiation and Viability of Neonatal Meniscus.International journal of molecular sciences · 2021Article
- Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Intrinsic and growth-mediated cell and matrix specialization during murine meniscus tissue assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Hypoxia as a Stimulus for the Maturation of Meniscal Cells: Highway to Novel Tissue Engineering Strategies?International journal of molecular sciences · 2021Article
- Evolution of Meniscal Biomechanical Properties with Growth: An Experimental and Numerical Study.Bioengineering (Basel, Switzerland) · 2021Article
- Perspective: Challenges Presented for Regeneration of Heterogeneous Musculoskeletal Tissues that Normally Develop in Unique Biomechanical Environments.Frontiers in bioengineering and biotechnology · 2021Review
- Histologically Confirmed Recellularization is a Key Factor that Affects Meniscal Healing in Immature and Mature Meniscal Tears.Frontiers in cell and developmental biology · 2021Article
- No detectable remodelling in adult human menisci: an analysis based on the CBritish journal of sports medicine · 2020Article
- Article
- Maturation of the Meniscal Collagen Structure Revealed by Polarization-Resolved and Directional Second Harmonic Generation Microscopy.Scientific reports · 2019Article
- Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages.Stem cells translational medicine · 2019Article
- Cell migration: implications for repair and regeneration in joint disease.Nature reviews. Rheumatology · 2019Review
- Maturation-Related Changes in T2 Relaxation Times of Cartilage and Meniscus of the Pediatric Knee Joint at 3 T.AJR. American journal of roentgenology · 2018Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The meniscus plays important roles in knee function and mechanics and is characterized by a heterogeneous matrix composition. The changes in meniscus vascularization observed during growth suggest that the tissue-specific composition may be the result of a maturation process. This study has the aim to characterize the structural and biochemical variations that occur in the swine meniscus with age. To this purpose, menisci were collected from young and adult pigs and divided into different zones. In study 1, both lateral and medial menisci were divided into the anterior horn, the body and the posterior horn for the evaluation of glycosaminoglycans (GAGs), collagen 1 and 2 content. In study 2, the menisci were sectioned into the inner, the intermediate and the outer zones to determine the variations in the cell phenotype along with the inner-outer direction, through gene expression analysis. According to the results, the swine meniscus is characterized by an increasing enrichment in the cartilaginous component with age, with an increasing deposition in the anterior horn (GAGs and collagen 2; P < 0.01 both); moreover, this cartilaginous matrix strongly increases in the inner avascular and intermediate zone, as a consequence of a specific differentiation of meniscal cells towards a cartilaginous phenotype (collagen 2, P < 0.01). The obtained data add new information on the changes that accompany meniscus maturation, suggesting a specific response of meniscal cells to the regional mechanical stimuli in the knee joint.
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