ArticleThe European journal of neuroscience2014
Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Lightweight Head-Mounted Optical Coherence Tomography Scope for Longitudinal, Intact-Skull Imaging of Ischemic Stroke in Freely Behaving Mouse.ACS photonics · 2026Article
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.Experimental neurology · 2026Article
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.bioRxiv : the preprint server for biology · 2025Article
- The role of spontaneous and evoked neuronal activity in protection from impending ischemic stroke during the hyperacute state.Scientific reports · 2025Article
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- Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion.Scientific reports · 2023Article
- Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion.Research square · 2023Article
- Sensory stimulation-based protection from impending stroke following MCA occlusion is correlated with desynchronization of widespread spontaneous local field potentials.Scientific reports · 2022Article
- Driving Oscillatory Dynamics: Neuromodulation for Recovery After Stroke.Frontiers in systems neuroscience · 2021Review
- Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia.Scientific reports · 2020Article
- Article
- Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.Experimental neurology · 2020Article
- Article
- An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice.Neural regeneration research · 2019Article
- Sensory Stimulation-Induced Astrocytic Calcium Signaling in Electrically Silent Ischemic Penumbra.Frontiers in aging neuroscience · 2019Article
- Sensory stimulation in acute stroke therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke.Nature reviews. Neurology · 2018Review
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- Prevention of the collapse of pial collaterals by remote ischemic perconditioning during acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Targeted ischemic stroke induction and mesoscopic imaging assessment of blood flow and ischemic depolarization in awake mice.Neurophotonics · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Using a rodent model of ischemic stroke [permanent middle cerebral artery occlusion (pMCAO)], our laboratory has previously demonstrated that sensory-evoked cortical activation via mechanical single whisker stimulation treatment delivered under an anesthetized condition within 2 h of ischemic onset confers complete protection from impending infarct. There is a limited time window for this protection; rats that received the identical treatment at 3 h following ischemic onset lost neuronal function and sustained a substantial infarct. Rats in these studies, however, were anesthetized with sodium pentobarbital or isoflurane, whereas most human stroke patients are typically awake. To optimize our animal model, the present study examined, using functional imaging, histological, and behavioral analysis, whether self-induced sensorimotor stimulation is also protective in unrestrained, behaving rats that actively explore an enriched environment. Rats were revived from anesthesia either immediately or at 3 h after pMCAO, at which point they were allowed to freely explore an enriched environment. Rats that explored immediately after ischemic onset maintained normal cortical function and did not sustain infarct, even when their whiskers were clipped. Rats that were revived at 3 h post-pMCAO exhibited eliminated cortical function and sustained cortical infarct. Further, the data suggested that the level of individual active exploration could influence the outcome. Thus, early activation of the ischemic cortical area via unrestrained exploration resulted in protection from ischemic infarct, whereas late activation resulted in infarct, irrespective of the level of arousal or whisker-specific stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.