ArticleEnvironmental science & technology2014
Environmental designer drugs: when transformation may not eliminate risk.
Article in Environmental science & technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Should Transformation Products Change the Way We Manage Chemicals?Environmental science & technology · 2024Article
- Co-selection for antibiotic resistance by environmental contaminants.npj antimicrobials and resistance · 2024Review
- enviRule: an end-to-end system for automatic extraction of reaction patterns from environmental contaminant biotransformation pathways.Bioinformatics (Oxford, England) · 2023Article
- Widespread formation of toxic nitrated bisphenols indoors by heterogeneous reactions with HONO.Science advances · 2022Article
- Computational Approaches for the Prediction of Environmental Transformation Products: Chlorination of Steroidal Enones.Environmental science & technology · 2021Article
- Immobilization of horseradish peroxidase on FeEnvironmental science and pollution research international · 2020Article
- Bioactive Rearrangement Products from Aqueous Photolysis of Pharmaceutical Steroids.Organic letters · 2019Article
- Transcriptomic Profiles in Zebrafish Liver Permit the Discrimination of Surface Water with Pollution Gradient and Different Discharges.International journal of environmental research and public health · 2018Article
- Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation.Environmental science & technology · 2017Article
- Concentrations of select dissolved trace elements and anthropogenic organic compounds in the Mississippi River and major tributaries during the summer of 2012 and 2013.Environmental monitoring and assessment · 2017Article
- Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays.Journal of visualized experiments : JoVE · 2016Article
- Coupled reversion and stream-hyporheic exchange processes increase environmental persistence of trenbolone metabolites.Nature communications · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Environmental transformation processes, including those occurring in natural and engineered systems, do not necessarily drastically alter molecular structures of bioactive organic contaminants. While the majority of generated transformation products are likely benign, substantial conservation of structure in transformation products can imply conservation or even creation of bioactivity across multiple biological end points and thus incomplete mitigation of ecological risk. Therefore, focusing solely on parent compound removal for contaminants of higher relative risk, the most common approach to fate characterization, provides no mechanistic relationship to potential biological effects and is inadequate as a comprehensive metric for reduction of ecological risks. Here, we explore these phenomena for endocrine-active steroid hormones, focusing on examples of conserved bioactivity and related implications for fate assessment, regulatory approaches, and research opportunities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.