ArticleGlobal health action2014
HIV, multidrug-resistant TB and depressive symptoms: when three conditions collide.
Article in Global health action, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Tuberculosis related disability: a systematic review and meta-analysis.BMC medicine · 2021Pooled it
- Pooled it
- Psycho-Socio-Economic Issues Challenging Multidrug Resistant Tuberculosis Patients: A Systematic Review.PloS one · 2016Pooled it
- Prevalence and predictors of depression in tuberculosis patients in india: a systematic review and meta-analysis.Discover mental health · 2025Review
- Mental Health Status and Its Impact on TB Treatment and Its Outcomes: A Scoping Literature Review.Frontiers in public health · 2022Article
- Psychiatric comorbidities among patients with complex drug-resistant tuberculosis in Mumbai, India.PloS one · 2022Article
- Psychological profile of multi drug resistance TB patients: A qualitative study from a Tertiary care Centre of Kolkata.Journal of family medicine and primary care · 2021Article
- "Death is a better option than being treated like this": a prevalence survey and qualitative study of depression among multi-drug resistant tuberculosis in-patients.BMC public health · 2020Article
- Comorbidities between tuberculosis and common mental disorders: a scoping review of epidemiological patterns and person-centred care interventions from low-to-middle income and BRICS countries.Infectious diseases of poverty · 2020Article
- The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis.Annals of general psychiatry · 2020Review
- Quality of life with tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2019Review
- Depression and HIV Disease Progression: A Mini-Review.Clinical practice and epidemiology in mental health : CP & EMH · 2019Review
- A Survey of Anxiety and Depressive Symptoms in Pulmonary Tuberculosis Patients With and Without Tracheobronchial Tuberculosis.Frontiers in psychiatry · 2018Article
- Alcohol use disorder and tuberculosis treatment: A longitudinal mixed method study in Thailand.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2017Article
- Quality of Life, Psychological Interventions and Treatment Outcome in Tuberculosis Patients: The Indian Scenario.Frontiers in psychology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManagement of multidrug-resistant TB (MDR-TB) patients co-infected with human immunodeficiency virus (HIV) is highly challenging. Such patients are subject to long and potentially toxic treatments and may develop a number of different psychiatric illnesses such as anxiety and depressive disorders. A mental health assessment before MDR-TB treatment initiation may assist in early diagnosis and better management of psychiatric illnesses in patients already having two stigmatising and debilitating diseases.
objectiveTo address limited evidence on the baseline psychiatric conditions of HIV-infected MDR-TB patients, we aimed to document the levels of depressive symptoms at baseline, and any alteration following individualized clinical and psychological support during MDR-TB therapy, using the Patient Health Questionnaire-9 (PHQ-9) tool, among HIV-infected patients.
designThis was a retrospective review of the medical records of an adult (aged >15 years) HIV/MDR-TB cohort registered for care during the period of August 2012 through to March 2014.
resultsA total of 45 HIV/MDR-TB patients underwent baseline assessment using the PHQ-9 tool, and seven (16%) were found to have depressive symptoms. Of these, four patients had moderate to severe depressive symptoms. Individualized psychological and clinical support was administered to these patients. Reassessments were carried out for all patients after 3 months of follow-up, except one, who died during the period. Among these 44 patients, three with baseline depressive symptoms still had depressive symptoms. However, improvements were observed in all but one after 3 months of follow-up.
conclusionPsychiatric illnesses, including depressive symptoms, during MDR-TB treatment demand attention. Routine administration of baseline mental health assessments by trained staff has the potential to assist in determining appropriate measures for the management of depressive symptoms during MDR-TB treatment, and help in improving overall treatment outcomes. We recommend regular monitoring of mental health status by trained counsellors or clinical staff, using simple, validated and cost-effective tools.
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