ReviewCurrent opinion in genetics & development2014
Comparative studies of gene regulatory mechanisms.
Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Stage-resolved gene regulatory network analysis reveals developmental reprogramming and genes with robust stem-preferred expression in sorghum.BMC plant biology · 2025Article
- Editorial: Model organisms in embryonic development.Frontiers in cell and developmental biology · 2025Article
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Prime time for primate functional genomics.Current opinion in genetics & development · 2020Review
- Gene expression profiling suggests differences in molecular mechanisms of fin elongation between cichlid species.Scientific reports · 2019Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
- Evolution of DNA Methylation in Papio Baboons.Molecular biology and evolution · 2019Article
- Statistical modelling of CG interdistance across multiple organisms.BMC bioinformatics · 2018Article
- Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.BMC genomics · 2017Article
- Comparative transcriptomics in human and mouse.Nature reviews. Genetics · 2017Review
- The evolution of the human genome.Current opinion in genetics & development · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
It has become increasingly clear that changes in gene regulation have played an important role in adaptive evolution both between and within species. Over the past five years, comparative studies have moved beyond simple characterizations of differences in gene expression levels within and between species to studying variation in regulatory mechanisms. We still know relatively little about the precise chain of events that lead to most regulatory adaptations, but we have taken significant steps towards understanding the relative importance of changes in different mechanisms of gene regulatory evolution. In this review, we first discuss insights from comparative studies in model organisms, where the available experimental toolkit is extensive. We then focus on a few recent comparative studies in primates, where the limited feasibility of experimental manipulation dictates the approaches that can be used to study gene regulatory evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.