Evidence map›Paper›PMID 25215305›Full record

ArticleJournal of diabetes research2014

Subjects with impaired fasting glucose: evolution in a period of 6 years.

E Leiva, V Mujica, R Orrego, S Wehinger, A Soto, G Icaza, M Vásquez, L Díaz, M Andrews, M Arredondo

Registry-linked trialAbstract read
In one paragraph

Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617757 (Determinants of Progression From Impaired Fasting Glucose to Diabetes Mellitus Among Chinese - a 3-year Follow up Study), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03617757 nacompletednot on this mapstarted 2017, after this paper: background citation

Determinants of Progression From Impaired Fasting Glucose to Diabetes Mellitus Among Chinese - a 3-year Follow up Study

TypeinterventionalSponsorThe University of Hong KongRan2017 to 2019Enrolled386ConditionsProgression From Impaired Fasting Glucose to Diabetes MellitusArmsOral Glucose Tolerance Test, HbA1c
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Evaluating gestational weight gain recommendations in pregestational diabetes.American journal of obstetrics and gynecology · 2015
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

E LeivaPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
V MujicaFacultad de Medicina, Universidad Católica del Maule, Avenida San Miguel 3605, 3480112 Talca, Chile.
R OrregoPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
S WehingerPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
A SotoPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Instituto de Matemáticas y Física, Universidad de Talca, Chile 2 Norte 685, 3465548 Talca, Chile.
G IcazaPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Instituto de Matemáticas y Física, Universidad de Talca, Chile 2 Norte 685, 3465548 Talca, Chile.
M VásquezPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
L DíazPrograma de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
M AndrewsLaboratorio de Micronutrientes, INTA, Universidad de Chile, El Líbano 5524, Macul, 7830490 Santiago, Chile.
M ArredondoLaboratorio de Micronutrientes, INTA, Universidad de Chile, El Líbano 5524, Macul, 7830490 Santiago, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the evolution of impaired fasting glucose (IFG), considering glucose and HbA1c levels and risk factors associated, in a period of 6 years.

methodsWe studied 94 subjects with impaired fasting glucose (IFG) that were diagnosed in 2005 and followed up to 2012. Glucose and HbA1c levels were determined. A descriptive analysis of contingence charts was performed in order to study the evolution in the development of type-2 diabetes mellitus (T2DM).

resultsTwenty-eight of ninety-four subjects became T2DM; 51/94 remained with IFG; and 20/94 presented normal fasting glucose. From the 28 diabetic subjects, 9 had already developed diabetes and were under treatment with oral hypoglycemic agents; 5 were diagnosed with plasma glucose < 126 mg/dL, but with HbA1c over 6.5%. In those who developed diabetes, 15/28 had a family history of T2DM in first relative degree. Also, diabetic subjects had a BMI significantly higher than nodiabetics (t test: P < 0.01). The individuals that in 2005 had the highest BMI are those who currently have diabetes.

conclusionThe IFG constitutes a condition of high risk of developing T2DM in a few years, especially over 110 mg/dL and in obesity patients.

Indexed as

Administration, OralAdultAgedAged, 80 and overBiomarkersBlood GlucoseBody Mass IndexChileDiabetes Mellitus, Type 2Disease ProgressionFastingFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGlucose Metabolism DisordersGlycated HemoglobinBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agents

Identifiers

PMID25215305
PMCPMC4158147

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.