Evidence map›Paper›PMID 25215267›Full record

ArticleCurrent behavioral neuroscience reports2014

Animal Models of Psychosis: Current State and Future Directions.

Alexandra D Forrest, Carlos A Coto, Steven J Siegel

Abstract read
In one paragraph

Article in Current behavioral neuroscience reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  20. Animal Models of Psychosis in Alzheimer Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra D ForrestTranslational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104.
Carlos A CotoTranslational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104.
Steven J SiegelTranslational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104.

Funding

NMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BILKER, WARREN B. · 2012 to 2016
$10.6M
An Implantable Semiannual Antipsychotic Delivery SystemR01MH074672 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, STEVEN J · 2007 to 2014
$2.3M
Long-term neurobehavioral effects of ketamine exposure in adolescent miceR01DA023210 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, STEVEN J · 2008 to 2012
$1.9M
Brain-Based Treatment--Impaired Cognition SchizophreniaR13MH078710 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARTER, CAMERON S. · 2006 to 2010
$589k
NIDA NIH HHS R01 DA023210NIMH NIH HHS P50 MH096891NIMH NIH HHS R01 MH074672NIMH NIH HHS R13 MH078710
6 · The paper itself

Abstract

Psychosis is an abnormal mental state characterized by disorganization, delusions and hallucinations. Animal models have become an increasingly important research tool in the effort to understand both the underlying pathophysiology and treatment of psychosis. There are multiple animal models for psychosis, with each formed by the coupling of a manipulation and a measurement. In this manuscript we do not address the diseases of which psychosis is a prominent comorbidity. Instead, we summarize the current state of affairs and future directions for animal models of psychosis. To accomplish this, our manuscript will first discuss relevant behavioral and electrophysiological measurements. We then provide an overview of the different manipulations that are combined with these measurements to produce animal models. The strengths and limitations of each model will be addressed in order to evaluate its cross-species comparability.

Indexed as

Animal ModelBehaviorElectroencephalographyPharmacological ManipulationPsychosisTransgenic Mice

Identifiers

PMID25215267
PMCPMC4157659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.