ReviewWorld journal of emergency medicine2013
Safety of epinephrine for anaphylaxis in the emergency setting.
Review in World journal of emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04755881 (SHARED), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SHARED (Saguenay Hospitals Anaphylaxis Rule for Early Discharge) - Phase 2 : a Prospective Theoretical Validation
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sublingual Immunotherapy Tablets Relieve Symptoms in Adults with Allergic Rhinitis: A Meta-analysis of Randomized Clinical Trials.Chinese medical journal · 2018Pooled it
- Comparison of Systemic Exposure Between Epinephrine Delivered via Metered-Dose Inhalation and Intramuscular Injection.Journal of aerosol medicine and pulmonary drug delivery · 2025Trial
- Food Allergy Management for Adolescents Using Behavioral Incentives: A Randomized Trial.Pediatrics · 2023Trial
- Pharmacokinetic Study of Epinephrine Hydrofluoroalkane (Primatene MIST) Metered-Dose Inhaler.Journal of aerosol medicine and pulmonary drug delivery · 2020Trial
- Recombinant human diamine oxidase prevents histamine-induced hypoxia, shock and death in guinea pigs.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Article
- Intramuscular epinephrine in cardiac arrest: A systematic review.Resuscitation plus · 2025Review
- Study of epinephrine-induced cardiovascular adverse events in patients with anaphylaxis using two spontaneously reported adverse event databases from 2004 to 2024.Scientific reports · 2025Article
- Optimizing Adrenaline Administration in Anaphylaxis: Clinical Practice Considerations and Safety Insights.Clinical and translational allergy · 2025Review
- Characteristics and Outcomes of Anaphylaxis in Emergency Department Visits Among Older Adults.The journal of allergy and clinical immunology. In practice · 2025Article
- Level of Awareness of Certified Non-critical Care Physicians in Diagnosing, Managing, and Disposing Anaphylactic Cases.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024Article
- Implantable device with magnetically rotating disk for needle-free administrations of emergency drug.Bioengineering & translational medicine · 2023Article
- Hypertensive and Hypotensive Emergencies in Interventional Radiology.Seminars in interventional radiology · 2022Review
- Pilot Project of Special Emergency Medical Service Team for Anaphylaxis in Gangwon-do, Korea: Results from an Online Questionnaire Survey.Journal of Korean medical science · 2021Article
- Intramuscular adrenaline for out-of-hospital cardiac arrest is associated with faster drug delivery: A feasibility study.Resuscitation plus · 2021Article
- Emerging Therapies in Anaphylaxis: Alternatives to Intramuscular Administration of Epinephrine.Current allergy and asthma reports · 2021Review
- Got a Pen for Allergen Immunotherapy? Lessons from Near-Fatal Anaphylaxis with Pulmonary Edema.Journal of asthma and allergy · 2020Article
- Acute myocardial injury after administration of intravenous epinephrine for allergic reaction.SAGE open medical case reports · 2020Article
- Underuse of Epinephrine for Pediatric Anaphylaxis Victims in the Emergency Department: A Population-based Study.Allergy, asthma & immunology research · 2019Article
- Anaphylaxis-related Malpractice Lawsuits.The western journal of emergency medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms, inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its safety. The objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis, including other emergent conditions, treated in emergency care settings.
methodsA MEDLINE search using PubMed was conducted to identify articles that discuss the dosing, administration, and safety of epinephrine in the emergency setting for anaphylaxis and other conditions.
resultsEpinephrine is safe for anaphylaxis when given at the correct dose by intramuscular injection. The majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly dosed.
conclusionEpinephrine by intramuscular injection is a safe therapy for anaphylaxis but training may still be necessary in emergency care settings to minimize drug dosing and administration errors and to allay concerns about its safety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.