ArticleWorld journal of emergency medicine2012
Association of ALOX5AP with ischemic stroke in eastern Chinese.
Article in World journal of emergency medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Pooled it
- Genetic insights into 5-LOX-activating protein: a narrative review of disease associations.Human genomics · 2025Review
- Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran.Iranian journal of neurology · 2019Article
- Lack of association betweenNeuropsychiatric disease and treatment · 2019Article
- A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.International journal of clinical and experimental medicine · 2015Article
- Article
- Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times.World journal of emergency medicine · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background5-lipoxygenase protein (ALOX5AP) has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patients with ischemic stroke.
methodsUsing a case-control design, we studied 658 patients with ischemic stroke and 704 unrelated population-based controls who were age- and sex-matched. The 658 patients were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped.
resultsThe genotype frequencies of TG of the SNPs rs17222919 located in the promoter of the ALOX5AP gene were significantly higher in patients with ischemic stroke than in controls (OR (*)=1.34, 95%CI(*)=1.02-1.75), especially in patients with ischemic stroke caused by small-artery occlusion (SAO) (OR (*)=1.40, 95%CI(*)=1.02-1.93). Meanwhile, the genotype frequencies of TG and TG/GG were higher in female patients than in the controls. After specification, the genotype frequencies of TG and TG/GG were higher in the patients than in controls with hypertension. The genotype frequencies of AG and AG/GG of the SNPs rs9579646 located in the intron of the ALOX5AP gene were higher in the controls than in the patients. After specification, the genotype frequencies of TG were higher in the controls than patients without hypertension.
conclusionThe present study suggests that sequence variants in the ALOX5AP gene are significantly associated with ischemic stroke.
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