Evidence map›Paper›PMID 25214997›Full record

ArticleWorld journal of emergency medicine2011

Effects of high-volume hemofiltration on alveolar-arterial oxygen exchange in patients with refractory septic shock.

Hong-Sheng Ren, Shi-Xue Gao, Chun-Ting Wang, Yu-Feng Chu, Jin-Jiao Jiang, Ji-Cheng Zhang, Mei Meng, Guo-Qian Qi, Min Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of emergency medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Sheng RenIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Shi-Xue GaoIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Chun-Ting WangIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Yu-Feng ChuIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Jin-Jiao JiangIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Ji-Cheng ZhangIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Mei MengIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Guo-Qian QiIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).
Min DingIntensive Care Unit, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China (Ren HS, Wang CT, Chu YF, Jiang JJ, Zhang JC, Meng M, Qi GQ, Ding M); Department of Intensive Care Unit, Shandong Province Feixian People's Hospital, Feixian 273400, China (Gao SX).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-volume hemofiltration (HVHF) is technically possible in severe acute pancreatitis (SAP) patients complicated with multiple organ dysfunction syndrome (MODS). Continuous HVHF is expected to become a beneficial adjunct therapy for SAP complicated with MODS. In this study, we aimed to explore the effects of fluid resuscitation and HVHF on alveolar-arterial oxygen exchange, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in patients with refractory septic shock.

methodsA total of 89 refractory septic shock patients, who were admitted to ICU, the Provincial Hospital affiliated to Shandong University from August 2006 to December 2009, were enrolled in this retrospective study. The patients were randomly divided into two groups: fluid resuscitation (group A, n=41), and fluid resuscitation plus high-volume hemofiltration (group B, n=48). The levels of O2 content of central venous blood (CcvO2), arterial oxygen content (CaO2), alveolar-arterial oxygen pressure difference P(A-a)DO2, ratio of arterial oxygen pressure/alveolar oxygen pressure (PaO2/PaO2), respiratory index (RI) and oxygenation index (OI) were determined. The oxygen exchange levels of the two groups were examined based on the arterial blood gas analysis at different times (0, 24, 72 hours and 7 days of treatment) in the two groups. The APACHE II score was calculated before and after 7-day treatment in the two groups.

resultsThe levels of CcvO2, CaO2 on day 7 in group A were significantly lower than those in group B (CcvO2: 0.60±0.24 vs. 0.72±0.28, P<0.05; CaO2: 0.84±0.43 vs. 0.94±0.46, P<0.05). The level of oxygen extraction rate (O2ER) in group A on the 7th day was significantly higher than that in group B (28.7±2.4 vs. 21.7±3.4, P<0.01). The levels of P(A-a)DO2 and RI in group B on the 7th day were significantly lower than those in group A. The levels of PaO2/PaO2 and OI in group B on 7th day were significantly higher than those in group A (P<0.05 or P<0.01). The APACHE II score in the two groups reduced gradually after 7-day treatment, and the APACHE II score on the 7th day in group B was significantly lower than that in group A (8.2±3.8 vs. 17.2±6.8, P<0.01).

conclusionHVHF combined with fluid resuscitation can improve alveolar-arterial-oxygen exchange, decrease the APACHE II score in patients with refractory septic shock, and thus it increases the survival rate of patients.

Indexed as

Acute Physiology and Chronic Health Evaluation II (APACHE II)Alveolar-arterial oxygen exchangeFluid resuscitationHigh-volume hemofiltrationOxygenation indexOxygen extraction ratePaO2/PaO2 ratioRespiratory indexSeptic shock

Identifiers

PMID25214997
PMCPMC4129696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.