Evidence map›Paper›PMID 25214881›Full record

ArticleFuture virology2014

Picornavirus infection leading to immunosuppression.

Matthew F Cusick, Jane E Libbey, Robert S Fujinami

Open access · greenAbstract read
In one paragraph

Article in Future virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew F CusickDepartment of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
Jane E LibbeyDepartment of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
Robert S FujinamiDepartment of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
University of Utah · US

Funding

Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
Virus Infection Leads to Autoreactive T Cells Having Multiple TCRsR01NS082102 · NINDS · UNIVERSITY OF UTAH · PI FUJINAMI, ROBERT S · 2013 to 2017
$1.6M
NIAID NIH HHS T32 AI055434NINDS NIH HHS R01 NS082102
6 · The paper itself

Abstract

Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few changes in the viral genome of a nonlethal virus can lead to an alteration in disease, from survivable to immunosuppression and death, would provide valuable information into viral pathogenesis. In addition, we propose that gaining a better insight into how these viruses suppress an antiviral immune response could lead to viral-based therapeutics to combat specifc autoimmune diseases such as multiple sclerosis and Type 1 diabetes.

Indexed as

autoimmune diseaseimmunosuppressionPicornavirusT cellTheiler's virus

Identifiers

PMID25214881
PMCPMC4157677
OpenAlexW2133201446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.