Evidence map›Paper›PMID 25214878›Full record

ArticleSoft matter2011

Chemically well-defined self-assembled monolayers for cell culture: toward mimicking the natural ECM.

Gregory A Hudalla, William L Murphy

Open access · greenAbstract read
In one paragraph

Article in Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
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  13. Dual-functionalized nanostructured biointerfaces by click chemistry.Langmuir : the ACS journal of surfaces and colloids · 2014
    Article
  14. Article
  15. Article
  16. Patterned self-assembled monolayers: efficient, chemically defined tools for cell biology.Chembiochem : a European journal of chemical biology · 2012
    Review
  17. Article
  18. Surfaces that sequester serum-borne heparin amplify growth factor activity.Advanced materials (Deerfield Beach, Fla.) · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gregory A HudallaDepartment of Biomedical Engineering, University of Wisconsin, 5009 Wisconsin Institutes of Medical Research, 1111 Highland Ave., Madison, WI, 53705, USA.
William L MurphyDepartment of Biomedical Engineering, University of Wisconsin, 5009 Wisconsin Institutes of Medical Research, 1111 Highland Ave., Madison, WI, 53705, USA ; Department of Pharmacology, University of Wisconsin, 5009 Wisconsin Institutes of Medical Research, 1111 Highland Ave., Madison, WI, 53705, USA ; Department of Orthopedics and Rehabilitation, University of Wisconsin, 5009 Wisconsin Institutes of Medical Research, 1111 Highland Ave., Madison, WI, 53705, USA.
Wisconsin Institutes for Discovery · US

Funding

Biomaterials for local regulation of growth factor signalingR01HL093282 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, WILLIAM L. · 2009 to 2018
$3.3M
Towards a synthetic basement membrane for the corneal epitheliumR01EY017367 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI NEALEY, PAUL F. · 2007 to 2010
$1.4M
NEI NIH HHS R01 EY017367NHLBI NIH HHS R01 HL093282
6 · The paper itself

Abstract

The extracellular matrix (ECM) is a network of biological macromolecules that surrounds cells within tissues. In addition to serving as a physical support, the ECM actively influences cell behavior by providing sites for cell adhesion, establishing soluble factor gradients, and forming interfaces between different cell types within a tissue. Thus, elucidating the influence of ECM-derived biomolecules on cell behavior is an important aspect of cell biology. Self-assembled monolayers (SAMs) have emerged as promising tools to mimic the ECM as they provide chemically well-defined substrates that can be precisely tailored for specific cell culture applications, and their application in this regard is the focus of this review. In particular, this review will describe various approaches to prepare SAM-based culture substrates

Identifiers

PMID25214878
PMCPMC4159093
OpenAlexW1973656982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.