ArticleNeuropsychiatric disease and treatment2014
Decreased mean platelet volume in panic disorder.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Meta-analysis of peripheral mean platelet volume in patients with mental disorders: Comparisons in depression, anxiety, bipolar disorder, and schizophrenia.Brain and behavior · 2023Pooled it
- Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders.International journal of environmental research and public health · 2022Article
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Changes in mean platelet volume and hematologic indices in patients with panic disorder due to oxidative stress.Brain and behavior · 2020Article
- Platelet and Red Blood Cell Indices in Patients with Panic Disorder: A Receiver Operating Characteristic Analysis.Journal of neurosciences in rural practice · 2020Article
- The effect of preoperative anxiety level on mean platelet volume and propofol consumption.BMC anesthesiology · 2020Article
- Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder.Neuropsychiatric disease and treatment · 2019Article
- Increased mean platelet volume in patients with idiopathic subjective tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder.Neuropsychiatric disease and treatment · 2016Article
- Increased mean platelet volume in patients with panic disorder.Neuropsychiatric disease and treatment · 2015Article
- Mean Platelet Volume and Platelet Distribution Width Level in Patients with Panic Disorder.Journal of neurosciences in rural practiceArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe relationship between psychological stress and platelet activation has been widely studied. It is well known that platelets may reflect certain biochemical changes that occur in the brain when different mental conditions occur. Platelet 5-hydroxytryptamine (5-HT) is also extensively studied in psychiatry. The mean platelet volume (MPV), the accurate measure of platelet size, has been considered a marker and determinant of platelet function. The aim of the present study was to search for any probable difference in the MPV of subjects with panic disorder (PD).
methodsA total of 37 drug-free subjects, aged 18 to 65 years, diagnosed with PD, with or without agoraphobia, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV) criteria and 45 healthy control subjects were included in the study. Platelet count and MPV were measured and recorded for each subject.
resultsThere were no statistically significant differences between groups in terms of female/male ratio, age, or body mass index between the PD group and control group (P=0.91, P=0.82, and P=0.93, respectively). The MPV was found to be significantly lower in the PD group compared with the control group (8.8±0.9 fL vs 9.2±0.8 fL; P=0.02). All the participants had MPV values in the standard range of 6.9-10.8 fL.
conclusionWe concluded that abnormalities of the 5-HT1A receptor function in the central nervous system of subjects with a diagnosis of PD are also mirrored in as an alteration in platelet activity. Measurements of platelet activity may be used as a tool for neuropsychiatric and psychopharmacological research and for studying how certain mental diseases and medications affect the central nervous system.
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