ArticleInternational journal of nanomedicine2014
Magnetic particle imaging: kinetics of the intravascular signal in vivo.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Elemental and biomolecular changes in serum as indicators of SPION action in the body: analysis using TXRF, FTIR and Raman spectroscopy.Scientific reports · 2025Article
- Cardiovascular Imaging Applications, Implementations, and Challenges Using Novel Magnetic Particle Imaging.Bioengineering (Basel, Switzerland) · 2025Review
- Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile.Journal of nanobiotechnology · 2024Article
- Article
- Long circulating tracer tailored for magnetic particle imaging.Nanotheranostics · 2021Article
- Optimal scanning concentration of MR imaging for tumor-bearing nude mice with SPIO-shRNA molecular probe.Scientific reports · 2020Article
- In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles.Scientific reports · 2020Article
- Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model.Scientific reports · 2020Article
- MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation.Nanomaterials (Basel, Switzerland) · 2019Article
- Tracking the Growth of Superparamagnetic Nanoparticles with an In-Situ Magnetic Particle Spectrometer (INSPECT).Scientific reports · 2019Article
- Human-sized magnetic particle imaging for brain applications.Nature communications · 2019Article
- A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging.AJNR. American journal of neuroradiology · 2019Review
- Magnetic particle imaging in vascular medicine.Innovative surgical sciences · 2018Review
- Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells.ACS applied nano materials · 2018Article
- Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil.Scientific reports · 2017Article
- Magnetic Particle Imaging (MPI): Experimental Quantification of Vascular Stenosis Using Stationary Stenosis Phantoms.PloS one · 2017Article
- Accumulation and Toxicity of Superparamagnetic Iron Oxide Nanoparticles in Cells and Experimental Animals.International journal of molecular sciences · 2016Article
- Article
- Tunable... International Workshop on Magnetic Particle Imaging. International Workshop on Magnetic Particle Imaging · 2015Article
- Magnetic particle imaging: current developments and future directions.International journal of nanomedicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnetic particle imaging (MPI) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles (SPIO). Today, Resovist(®) is still the reference SPIO for MPI. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma AG, and one from I'rom Pharmaceutical Co Ltd) in MPI.
methodsA Resovist concentration of 50 μmol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I'rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma AG. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 minutes until 120 minutes after the injection. The MPI signal of the blood samples was evaluated using magnetic particle spectroscopy.
resultsThe average decline of the blood MPI signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma AG showed a slower decline of the MPI signal (39.7% after 5 minutes, 20.5% after 10 minutes, and 12.1% after 15 minutes) compared with Resovist produced by I'rom Pharmaceutical Co Ltd (20.4% after 5 minutes, 7.8% after 10 minutes, no signal above noise level after 15 minutes).
conclusionIn MPI, the blood half-life of an SPIO tracer cannot be equalized to the blood half-life of its MPI signal. Resovist shows a very rapid decline of blood MPI signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in MPI, it may be used as a bolus tracer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.