ArticleInfection and immunity1989
C3bi-binding protein on Candida albicans: temperature-dependent expression and relationship to human complement receptor type 3.
Article in Infection and immunity, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens.FEMS yeast research · 2015Review
- Interactions of Candida albicans with host epithelial surfaces.Journal of oral microbiology · 2013Review
- Review
- Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis.Infection and immunity · 2008Review
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- The effects of monoclonal antibodies against iC3b receptors in mice with experimentally induced disseminated candidiasis.Immunology · 1997Article
- Distinct characteristics of initiation of the classical and alternative complement pathways by Candida albicans.Infection and immunity · 1996Article
- Activation of the complement system by pathogenic fungi.Clinical microbiology reviews · 1996Review
- Reduced inhibition of Candida albicans adhesion by saliva from patients receiving oral cancer therapy.Journal of clinical microbiology · 1995Article
- Adherence of Candida albicans to human buccal epithelial cells: host-induced protein synthesis and signaling events.Infection and immunity · 1995Article
- Ca ions stabilize the binding of complement factor iC3b to the pseudohyphal form of Candida albicans.Infection and immunity · 1994Article
- Adhesins and ligands involved in the interaction of Candida spp. with epithelial and endothelial surfaces.Clinical microbiology reviews · 1994Review
- Complement-related proteins in pathogenic organisms.Springer seminars in immunopathology · 1994Review
- Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis. Identification of the participating ligands and development of inhibitory peptides.The Journal of clinical investigation · 1993Article
- Isolation of avirulent clones of Candida albicans with reduced ability to recognize the CR2 ligand C3d.Infection and immunity · 1993Article
- Isolation and biochemical characterization of the iC3b receptor of Candida albicans.Infection and immunity · 1993Article
- Cell extracts of Candida albicans block adherence of the organisms to endothelial cells.Infection and immunity · 1992Article
- A role for complement receptor-like molecules in iron acquisition by Candida albicans.The Journal of experimental medicine · 1992Article
- Evidence that Candida albicans binds via a unique adhesion system on phagocytic cells in the marginal zone of the mouse spleen.Infection and immunity · 1992Article
- Interactions between conidia of Aspergillus fumigatus and human complement component C3.Infection and immunity · 1992Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated in detail the previously described capacity of pseudohyphae of Candida albicans to bind C3-coated particles. We show that the expression of the C3bi receptor of C. albicans was dependent upon the growth temperature of the fungi. C. albicans grown at 30 degrees C bound strongly to EAC1423bi, whereas those cells grown at 38.5 degrees C were completely devoid of this capacity. The molecule responsible for the attachment of EAC1423bi was heat labile and trypsin sensitive. Several, but not all, monoclonal antibodies to the alpha-chain of human complement receptor type 3 (CR3) stained C. albicans, and this reactivity was expressed in parallel with the capacity of C. albicans to bind EAC1423bi, i.e., both were dependent on the growth temperature of the fungi and were trypsin sensitive. In contrast to CR3, the binding of EAC1423bi to C. albicans did not require the presence of divalent cations. Rabbit immunoglobulin G antibodies directed against C. albicans inhibited the binding of EAC1423bi to C. albicans but not to human CR3. These inhibiting IgG antibodies recognized antigens expressed on the surface of pseudohyphae but not those of yeast cells. OKM-1, a monoclonal antibody to human CR3 inhibited the attachment of EAC1423bi to CR3 and also to C. albicans. OKM-1 precipitated a 130-kilodalton band from solubilized 125I-labeled C. albicans. We conclude that the complement receptors on C. albicans and human CR3 were antigenically related but not identical and that they differed in their functional characteristics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.