ArticleHuman genetics1989
The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.
Article in Human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank.Genes · 2021Article
- Structure, function, and genetics of lipoprotein (a).Journal of lipid research · 2016Review
- Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.American journal of human genetics · 1995Article
- Lipoprotein(a): new insights into an atherogenic lipoprotein.The Clinical investigator · 1994Review
- Lipoprotein(a) and its role in occlusive vascular disease.Annals of the Royal College of Surgeons of England · 1993Review
- The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration.Human genetics · 1992Article
- Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.American journal of human genetics · 1992Article
- Expressed hypervariable polymorphism of apolipoprotein (a).American journal of human genetics · 1991Article
- Lipoprotein(a): nonhuman primate models.Lipids · 1991Review
- Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.The Journal of clinical investigation · 1991Article
- Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups.Human genetics · 1991Article
- Characterization of the enzyme activity of human plasma lipoprotein (a) using synthetic peptide substrates.The Biochemical journal · 1991Article
- Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.Molecular and cellular biology · 1990Article
- Lipoprotein (a). Heterogeneity and biological relevance.The Journal of clinical investigation · 1990Review
- Variation in the size of human apolipoprotein(a) is due to a hypervariable region in the gene.Human genetics · 1990Article
- Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.The EMBO journal · 1989Article
- Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the segregation of the Lp(a) glycoprotein phenotypes and of the plasminogen (PLG) polymorphism in three two-generation families. The inheritance of the Lp(a) gene was followed using the Lp(a) glycoprotein size polymorphism and that of the plasminogen gene, using protein and DNA polymorphisms. In the three families studied, no recombination was observed in 18 meioses. The lod score for linkage between the Lp(a) glycoprotein locus and the plasminogen locus in these families is greater than 5.0 at a recombination fraction of theta = 0. Our results show that the structural gene for the Lp(a) glycoprotein is closely linked to the gene for plasminogen on chromosome 6.
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