ReviewJournal of international oral health : JIOH2014
Oral fluid based biomarkers in periodontal disease: part 1. Saliva.
Review in Journal of international oral health : JIOH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.BMC oral health · 2025Article
- The Association Between Periodontal Inflamed Surface Area (PISA), Inflammatory Biomarkers, and Mitochondrial DNA Copy Number.Journal of clinical medicine · 2024Article
- A REVIEW OF SALIVARY BIOMARKERS OF PERIODONTAL DISEASE.Annals of Ibadan postgraduate medicine · 2024Article
- Progress in salivary glands: Endocrine glands with immune functions.Frontiers in endocrinology · 2023Review
- Evaluation of cannabinoid receptors type 1-2 in periodontitis patients.Clinical and experimental dental research · 2022Article
- Update on the Role of Cytokines as Oral Biomarkers in the Diagnosis of Periodontitis.Advances in experimental medicine and biology · 2022Article
- Detection of Salivary miRNAs That Predict Chronic Periodontitis Progression: A Cohort Study.International journal of environmental research and public health · 2021Article
- Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis.Frontiers in immunology · 2021Observational
- ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis.Biomedicines · 2020Article
- Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study.Molecules (Basel, Switzerland) · 2019Article
- Characterizing the Subgingival Microbiome of Pregnant African American Women.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2019Article
- Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers.Sultan Qaboos University medical journal · 2018Article
- Development of a Multiplexed Liquid Chromatography Multiple-Reaction-Monitoring Mass Spectrometry (LC-MRM/MS) Method for Evaluation of Salivary Proteins as Oral Cancer Biomarkers.Molecular & cellular proteomics : MCP · 2017Article
- Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure.Biological research for nursing · 2017Article
- Potential Use of Salivary Markers for Longitudinal Monitoring of Inflammatory Immune Responses to Vaccination.Mediators of inflammation · 2016Review
- Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria.Disease markers · 2015Article
- Functional biomarkers for chronic periodontitis and insights into the roles ofNPJ biofilms and microbiomes · 2015Article
- Analysis of protein expression in periodontal pocket tissue: a preliminary study.Proteome science · 2015Article
- Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge.Frontiers in cellular and infection microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional clinical measurements such as probing pocket depth, bleeding on probing, clinical attachment loss; plaque index and radiographs used for periodontal diagnosis are often of limited usefulness as they are indicators of previous periodontal disease rather than present disease activity. A literature search was carried out to find out all the available tests that indicate periodontal disease markers in saliva. All major databases were searched to compile the information on published reports between 1999 and 2014. The list of biomarkers available to date is compiled and presented in a table format. Each biomarker is discussed separately based on the available evidence. Based on the evidence, it can be concluded that several sensitive salivary indicators of periodontitis are available to detect the presence, severity and response to treatment. Further studies are warranted to analyze the sensitivity and reliability of these indicators that might help in developing non-invasive tests that could help in the diagnosis of periodontal disease.
Indexed as
Identifiers
25214743PMC4148585W2992579713What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.