Evidence map›Paper›PMID 25214544›Full record

ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2014

Cognitive function and fatigue after diagnosis of colorectal cancer.

J Vardy, H M Dhillon, G R Pond, S B Rourke, W Xu, A Dodd, C Renton, A Park, T Bekele, J Ringash and 4 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00188331 completednot on this map

Cognitive Function and Fatigue in Cancer Patients After Chemotherapy: A Longitudinal Controlled Study in Patients With Colorectal Cancer

TypeobservationalSponsorUniversity Health Network, TorontoRan2003 to 2015Enrolled441ConditionsCognition, Fatigue, Colorectal NeoplasmArmsNeuropsychological Testing
NCT03683004 completednot on this mapstarted 2018, after this paper: background citation

Chemotherapy-Related Changes in Neurocognitive Function and Symptoms in Colorectal Cancer Patients: A Pilot Study

TypeobservationalSponsorUniversity of NebraskaRan2018 to 2020Enrolled40ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  9. Quality of life among colorectal cancer survivors participating in a pilot randomized controlled trial of a web-based dietary intervention with text messages.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

J VardySydney Medical School, University of Sydney, Sydney, Australia; Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada; Concord Cancer Centre, Concord Hospital, Concord, Australia. Electronic address: janette.vardy@sydney.edu.au.
H M DhillonSydney Medical School, University of Sydney, Sydney, Australia.
G R PondDepartment of Oncology, McMaster University, Hamilton.
S B RourkeSt Michael's Hospital, University of Toronto, Toronto; The Ontario HIV Treatment Network, Toronto.
W XuPrincess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
A DoddPrincess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
C RentonSydney Medical School, University of Sydney, Sydney, Australia.
A ParkPrincess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
T BekeleThe Ontario HIV Treatment Network, Toronto.
J RingashPrincess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
H ZhangKeenan Research Centre for Biomedical Research, St Michael's Hospital, University of Toronto, Toronto.
R BurkesMt Sinai Hospital, University of Toronto, Toronto, Canada.
S J ClarkeSydney Medical School, University of Sydney, Sydney, Australia.
I F TannockPrincess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive impairment and fatigue have been associated with cancer and its treatment. We present baseline data from a large longitudinal study that evaluates cognitive function, fatigue, and potential underlying mechanisms following diagnosis of colorectal cancer (CRC). PATIENTS AND

methodsWe evaluated CRC patients with stage I-III disease before or after surgery, participants with limited metastatic disease and healthy controls (HC). Neuropsychological evaluation included clinical and computerised tests. Participants completed questionnaires for fatigue and quality of life (QOL)-(FACT-F), anxiety/depression, and cognitive symptoms (FACT-Cog). Ten cytokines, clotting factors, sex hormones, carcinoembryonic antigen (CEA), and apolipoprotein E genotype were evaluated. Primary end points were cognitive function on clinical tests evaluated by a Global Deficit score (GDS) and fatigue. Associations between test results, demographic, and disease related factors were explored.

resultsWe assessed 291 participants with early-stage disease [median age 59 (23-75) years, 63% men], 72 with metastatic disease, and 72 HC. Using GDS, 45% (126/281) of participants with early-stage CRC had cognitive impairment versus 15% (11/72) of HC (odds ratio 4.51, 95% confidence interval 2.28-8.93; P < 0.001), with complex processing speed, attention/working memory, and verbal learning efficiency being most affected. Women with early-stage CRC had greater cognitive impairment than men [55/105 (52%) versus 71/176 (40%), P < 0.050]. Cognitive symptoms were self-reported by 21% (59/286) of early-stage patients versus 17% (12/72) of HC; fatigue by 52% (149/287) of early-stage patients and 26% (19/72) of HC (P < 0.0001). Women reported more fatigue than men (P = 0.003). Fatigue, QOL, anxiety/depression, and cognitive symptoms were associated with each other (r = 0.43-0.71), but not with neuropsychological performance. Most cytokines were elevated in cancer patients. Cognitive function was not associated with cytokines, sex hormones, clotting factors, CEA, or apolipoprotein E genotype.

conclusionsThe incidence of cognitive impairment was three to five times higher in CRC patients than HC, with women having higher impairment rates than men. The cognitive impairment profile suggests dysfunction primarily in fronto-subcortical brain systems.

trial registrationNCT00188331.

Indexed as

CognitionFatigueAdultAgedColorectal NeoplasmsFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsYoung Adultcognitive functioncolorectal cancerfatiguequality of lifesurvivorship

Identifiers

PMID25214544
PMCPMC4239806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.