ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2015
MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Smoking induces different expression of miR-320b and miR-10b-5p in plasma extracellular vesicles of non-small cell lung cancer patients.The journal of liquid biopsy · 2025Article
- Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response.Cancer biomarkers : section A of Disease markers · 2024Article
- [Exosomal miR-10b Promotes Invasion and Epithelial-mesenchymal Transformation of Lung Adenocarcinoma A549 Cells by Regulating Macrophage M2 Polarization].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022Article
- Potential value of circulatory microRNA10b gene expression and its target E-cadherin as a prognostic and metastatic prediction marker for breast cancer.Journal of clinical laboratory analysis · 2021Article
- EMT Factors and Metabolic Pathways in Cancer.Frontiers in oncology · 2020Review
- MicroRNA in Lung Cancer Metastasis.Cancers · 2019Review
- MicroRNA 615-3p Inhibits the Tumor Growth and Metastasis of NSCLC via Inhibiting IGF2.Oncology research · 2019Article
- Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095.American journal of translational research · 2019Article
- Circulating MiR-10b, MiR-1 and MiR-30a Expression Profiles in Lung Cancer: Possible Correlation with Clinico-pathologic Characteristics and Lung Cancer Detection.International journal of molecular and cellular medicine · 2019Article
- OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers.Scientific reports · 2018Article
- DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients.The Journal of pathology · 2018Article
- Decoding the Emerging Patterns Exhibited in Non-coding RNAs Characteristic of Lung Cancer with Regard to their Clinical Significance.Current genomics · 2018Article
- The fundamental role of miR-10b in metastatic cancer.American journal of cancer research · 2018Review
- Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC.OncoTargets and therapy · 2018Article
- Potent and selective effect of the mir-10b inhibitor MN-anti-mir10b in human cancer cells of diverse primary disease origin.PloS one · 2018Article
- The microRNA miR-10b as a potentially promising biomarker to predict the prognosis of cancer patients: a meta-analysis.Oncotarget · 2017Article
- Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo.Scientific reports · 2017Article
- MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor.Oncology letters · 2017Article
- miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma.Cell proliferation · 2016Article
- Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer.Oncology letters · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
backgroundMicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis. It was previously found to be a tumor enhancer in NSCLC; however, its clinical significance in NSCLC has not been evaluated.
methodsWe compared the expression levels of miR-10b in 73 pairs of NSCLC tissues and the corresponding noncancerous tissues, as well as in human lung cancer cell line A549 and NHBE cell line by qRT-PCR. Expression of E-cadherin (E-cad) was detected using RT-PCR and Western blot analysis. The disease-specific survival (DSS) was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier.
resultsMiR-10b was significantly upregulated in NSCLC tissues as well as in A549 cell line. The relative miR-10b expression levels were significantly positively correlated with TNM stage (p = 0.01) and regional lymph node involvement (p < 0.001). Kaplan-Meier analysis showed that patients with higher levels of miR-10b had significantly poorer survival than those with lower expression of this miRNA in patients, with a 5-year DSS of 29.5 and 63.8 %, respectively (p = 0.003). The E-cad mRNA and protein were overexpressed in miR-10b-suppressed cells compared with controls.
conclusionOur results indicated that miR-10b expression was an independent prognostic factor in NSCLC patients. Furthermore, miR-10b might be necessary for driving the expression of E-cad in NSCLC.
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