ArticleJournal of shoulder and elbow surgery2015
Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear.
Article in Journal of shoulder and elbow surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Proteomic trajectories in human rotator cuff degeneration: a systematic review of immunohistochemical studies.Journal of orthopaedic surgery and research · 2026Pooled it
- Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis.Scientific reports · 2018Pooled it
- The effects of hyperlipidemia on rotator cuff diseases: a systematic review.Journal of orthopaedic surgery and research · 2018Pooled it
- Muscle Health & Fatty Infiltration with Advanced Rotator Cuff Pathology.Current reviews in musculoskeletal medicine · 2025Review
- Influence of statin use on progression of postoperative fatty infiltration in the arthroscopic rotator cuff repair.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Overexpression of PRDM16 improves muscle function after rotator cuff tears.Journal of shoulder and elbow surgery · 2024Article
- Rotator cuff tears.Nature reviews. Disease primers · 2024Review
- A causal association between lipid-lowering medications and rotator cuff syndrome: a drug-targeted mendelian randomization study.Frontiers in genetics · 2024Article
- Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury.Journal of surgery and research · 2024Article
- Current Research on the Influence of Statin Treatment on Rotator Cuff Healing.Clinics in orthopedic surgery · 2023Review
- Simvastatin Improves Benign Prostatic Hyperplasia: Role of Peroxisome-Proliferator-Activated Receptor-γ and Classic WNT/β-Catenin Pathway.International journal of molecular sciences · 2023Article
- Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture.Frontiers in bioengineering and biotechnology · 2022Article
- CCAAT/Enhancer-Binding Proteins in Fibrosis: Complex Roles Beyond Conventional Understanding.Research (Washington, D.C.) · 2022Review
- Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons.International journal of nanomedicine · 2022Article
- Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy.Skeletal muscle · 2021Article
- Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.Molecular neurobiology · 2021Article
- Engineering Musculoskeletal Grafts for Multi-Tissue Unit Repair: Lessons From Developmental Biology and Wound Healing.Frontiers in physiology · 2021Review
- Supraspinatus muscle shear wave elastography (SWE): detection of biomechanical differences with varying tendon quality prior to gray-scale morphologic changes.Skeletal radiology · 2020Article
- The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic rotator cuff tears are a common source of shoulder pain and disability, and patients with chronic cuff tears often have substantial weakness, fibrosis, inflammation, and fat accumulation. Identifying therapies to prevent the development of these pathologic processes will likely have a positive impact on clinical outcomes. Simvastatin is a drug with demonstrated anti-inflammatory and antifibrotic effects in many tissues but had not previously been studied in the context of rotator cuff tears. We hypothesized that after the induction of a massive supraspinatus tear, simvastatin would protect muscles from a loss of force production and fibrosis.
methodsWe measured changes in muscle fiber contractility, histology, and biochemical markers of fibrosis and fatty infiltration in rats that received a full-thickness supraspinatus tear and were treated with either carrier alone or simvastatin.
resultsCompared with vehicle-treated controls, simvastatin did not have an appreciable effect on muscle fiber size, but treatment did increase muscle fiber specific force by 20%. Simvastatin also reduced collagen accumulation by 50% but did not affect triglyceride content of muscles. Several favorable changes in the expression of genes and other markers of inflammation, fibrosis, and regeneration were also observed.
conclusionsSimvastatin partially protected muscles from the weakness that occurs as a result of chronic rotator cuff tear. Fibrosis was also markedly reduced in simvastatin-treated animals. Whereas further studies are necessary, statin medication could potentially help improve outcomes for patients with rotator cuff tears.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.