Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Detection of post-exercise stunning by early gated SPECT myocardial perfusion imaging: results from the IAEA multi-center study.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- The Value of Stress-Gated Blood Pool SPECT in Predicting Early Postoperative Period Complications in Ischemic Cardiomyopathy Patients: Focus on Mechanical Dyssynchrony.Journal of clinical medicine · 2023Article
- Prognostic value of absent left ventricular ejection fraction reserve with regadenoson SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Impact of early post-stressThe international journal of cardiovascular imaging · 2021Article
- Prolonged left ventricular dysfunction following pharmacologic stress myocardial perfusion imaging: Should we be less stunned than in the past?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Better characterization of dipyridamole-induced myocardial stunning by systolic wall thickening. A gated perfusion SPECT study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular mechanical dyssynchrony for CAD diagnosis: Does it have incremental clinical values?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Myocardial stunning by gated SPECT: An old tool reinvented in a stunning turn.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging.Nuclear medicine communications · 2018Article
- The right timing for post-ischemic stunning.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Fast myocardial perfusion imaging withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Myocardial perfusion imaging with 99mTc-labeled radiopharmaceuticals: How fast can a stress-rest same-day imaging protocol be completed?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Impact of imaging protocol on left ventricular ejection fraction using gated-SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Clinical value of hyperemic left ventricular systolic function in vasodilator stress testing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Combined assessment of myocardial perfusion and left ventricular function by nuclear cardiology: The value of high-efficiency SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- The prognostic value of non-perfusion variables obtained during vasodilator stress myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- CZT camera: moving beyond classical CAD detection?European journal of nuclear medicine and molecular imaging · 2015Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient post-ischemic LV dysfunction due to myocardial stunning in patients with coronary artery disease can be missed by conventional gated SPECT (GSPECT) acquisitions. The aim of this IAEA-sponsored multi-center study was to determine whether early post-exercise imaging is more likely to detect stunning than conventional without adversely affecting image quality or perfusion information. METHODS AND
resultsPatients undergoing exercise/rest GSPECT were enrolled in this international multicenter study. Post-exercise studies were acquired at 15 ± 5 minutes after radiotracer injection (Stress-1) and repeated at 60 ± 15 minutes (Stress-2). Rest studies (R) were acquired at 60 minutes post injection. A core laboratory quantitatively assessed perfusion pattern and LV blinded to the acquisition time. Ischemia was defined as summed stress score (SDS) ≥4, and stunning was defined as the difference between rest and post-stress LVEF (Δ-LVEF). In the 229 patients enrolled into the study, both image quality and perfusion information were similar between Stress-1 and Stress-2. Post-stress LVEF was associated with both ischemia and time of acquisition, with a significant correlation between SDS and Δ-LVEF, which was stronger at Stress-1 than Stress-2 in the ischemic compared to the non-ischemic population (r = 0.23 vs 0.08, P = 0.10).
conclusionsEarly post-exercise imaging is feasible, and can potentially improve the detection of post-ischemic stunning without compromising image quality and perfusion data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.