Evidence map›Paper›PMID 25213184›Full record

ArticleLeukemia & lymphoma2015

Integrated analysis of CRLF2 signaling in acute lymphoblastic leukemia identifies Polo-like kinase 1 as a potential therapeutic target.

Tai-Chung Huang, Jevon Cutler, Shubhada Bharne, Jun Zhong, David Weinstock, Jeffrey Tyner, Ivana Gojo, Curt Civin, Akhilesh Pandey

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Tai-Chung HuangMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Jevon Cutler
Shubhada Bharne
Jun Zhong
David Weinstock
Jeffrey Tyner
Ivana Gojo
Curt Civin
Akhilesh Pandey
Johns Hopkins Medicine · USUniversity of Maryland, Baltimore · USDana-Farber Cancer Institute · USJohns Hopkins University · USOHSU Knight Cancer InstituteSidney Kimmel Comprehensive Cancer Center · US

Funding

TCP5: ACTIVE SITE LABELING REAGENT FOR ACETYLTRANSFERASESU54RR020839 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BOEKE, JEF D · 2004 to 2011
$27.4M
Proteome Characterization Center: A Genoproteomics Pipeline for Cance ResearchU24CA160036 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2011 to 2016
$10.7M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
CRLF2 signaling in B-cell acute lymphoblastic leukemiaR01CA151898 · NCI · DANA-FARBER CANCER INST · PI WEINSTOCK, DAVID MARC · 2010 to 2019
$3.4M
NCI NIH HHS R01 CA151898NCI NIH HHS U24 CA160036NCRR NIH HHS U54 RR020839NHLBI NIH HHS HHSN268201000032CNIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Signal TransductionAnimalsAntineoplastic AgentsCell Cycle ProteinsDisease Models, AnimalHumansInhibitory Concentration 50Molecular Targeted TherapyPolo-Like Kinase 1Precursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, CytokineXenograft Model Antitumor AssaysAntineoplastic AgentsCell Cycle ProteinsCRLF2 protein, humanPolo-Like Kinase 1Protein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, Cytokine

Identifiers

PMID25213184
PMCPMC4420723
OpenAlexW2169439808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.