Evidence map›Paper›PMID 25213159›Full record

Trial reportThe British journal of psychiatry : the journal of mental science2014

Role of pill-taking, expectation and therapeutic alliance in the placebo response in clinical trials for major depression.

Andrew F Leuchter, Aimee M Hunter, Molly Tartter, Ian A Cook

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of psychiatry : the journal of mental science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00200902 (Factors of Treatment Response in Major Depressive Disorder), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00200902 phase4completednot on this map

Factors of Treatment Response in Major Depressive Disorder

TypeinterventionalSponsorUniversity of California, Los AngelesRan2005 to 2009Enrolled88ConditionsDepressionArmsVenlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro), Placebo, Interpersonal Clinical Interaction (ICI)
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  9. Pretreatment and early-treatment cortical thickness is associated with SSRI treatment response in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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  10. Placebo response in trichotillomania.International clinical psychopharmacology · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew F LeuchterAndrew F. Leuchter, MD, Aimee M. Hunter, PhD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles; Molly Tartter, MA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA and the Department of Psychology, University of California Los Angeles, Los Angeles; Ian A. Cook, MD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, California, USA.
Aimee M HunterAndrew F. Leuchter, MD, Aimee M. Hunter, PhD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles; Molly Tartter, MA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA and the Department of Psychology, University of California Los Angeles, Los Angeles; Ian A. Cook, MD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, California, USA.
Molly TartterAndrew F. Leuchter, MD, Aimee M. Hunter, PhD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles; Molly Tartter, MA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA and the Department of Psychology, University of California Los Angeles, Los Angeles; Ian A. Cook, MD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, California, USA.
Ian A CookAndrew F. Leuchter, MD, Aimee M. Hunter, PhD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles; Molly Tartter, MA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA and the Department of Psychology, University of California Los Angeles, Los Angeles; Ian A. Cook, MD, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Psychobiologic Factors of the Placebo Response in MDDR01AT002479 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEUCHTER, ANDREW F · 2004 to 2007
$1.3M
NCCIH NIH HHS R01 AT002479
6 · The paper itself

Abstract

backgroundPill-taking, expectations and therapeutic alliance may account for much of the benefit of medication and placebo treatment for major depressive disorder (MDD). Aims To examine the effects of medication, placebo and supportive care on treatment outcome, and the relationships of expectations and therapeutic alliance to improvement.

methodA total of 88 participants were randomised to 8 weeks of treatment with supportive care alone or combined with double-blind treatment with placebo or antidepressant medication. Expectations of medication effectiveness, general treatment effectiveness and therapeutic alliance were measured (trial registration at ClinicalTrials.gov: NCT00200902).

resultsMedication or placebo plus supportive care were not significantly different but had significantly better outcome than supportive care alone. Therapeutic alliance predicted response to medication and placebo; expectations of medication effectiveness at enrolment predicted only placebo response.

conclusionsPill treatment yielded better outcome than supportive care alone. Medication expectations uniquely predicted placebo treatment outcome and were formed by time of enrolment, suggesting that they were shaped by prior experiences outside the clinical trial.

Indexed as

Major Depressive DisorderPlacebo EffectAdultAntidepressive AgentsCombined Modality TherapyDouble-Blind MethodFemaleHumansInterview, PsychologicalMaleMiddle AgedMotivationPatient CompliancePsychiatric Status Rating ScalesPsychotherapyTreatment OutcomeAntidepressive Agents

Identifiers

PMID25213159
PMCPMC4248233
OpenAlexW2126272883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.