Evidence map›Paper›PMID 25213046›Full record

ReviewThe journal of allergy and clinical immunology. In practice

Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma.

E Kathryn Miller, Pedro C Avila, Yasmin W Khan, Carolyn R Word, Barry J Pelz, Nikolaos G Papadopoulos, R Stokes Peebles, Peter W Heymann, Microbes, Allergy, and Asthma Committee

Open access · bronzeAbstract readCase ReportsReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Trial
  3. Review
  4. Article
  5. Article
  6. [Clinical characteristics of different ages of children with acute exacerbation of bronchial asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

E Kathryn MillerDivision of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: eva.k.miller@Vanderbilt.edu.
Pedro C AvilaDivision of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, Ill.
Yasmin W KhanDivision of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn.
Carolyn R WordDivision of Respiratory Medicine, Allergy and Pulmonary, Department of Pediatrics, Asthma and Allergic Disease Center and Department of Pediatrics, University of Virginia, Charlottesville, Va.
Barry J PelzDivision of Allergy-Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Ill.
Nikolaos G PapadopoulosCentre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, United Kingdom; Allergy Department, Second Pediatric Clinic, University of Athens Medical School, Athens, Greece.
R Stokes PeeblesDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
Peter W HeymannDivision of Respiratory Medicine, Allergy and Pulmonary, Department of Pediatrics, Asthma and Allergic Disease Center and Department of Pediatrics, University of Virginia, Charlottesville, Va.
Microbes, Allergy, and Asthma Committee
Vanderbilt University · USUniversity of Virginia · USLurie Children's Hospital · USManchester Academic Health Science Centre · GB

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dawn C Newcomb · 2011 to 2026
$34.9M
Chicagoland Metropolitan AsthmaNet Consortium (CMAC)U10HL098096 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KRISHNAN, JERRY A., PONGRACIC, JACQUELINE · 2009 to 2015
$4.6M
The Role of Human Rhinoviruses in Premature Infant Respiratory Disease and AsthmaK23AI091691 · NIAID · VANDERBILT UNIVERSITY · PI MILLER, EVA KATHRYN · 2011 to 2015
$619k
Rates of rhinovirus species in adults and children with acute respiratory illnessR03AI101629 · NIAID · VANDERBILT UNIVERSITY · PI MILLER, EVA KATHRYN · 2012 to 2013
$156k
NCATS NIH HHS 2 UL1 TR000445-06NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR024975-01NHLBI NIH HHS HL98096NHLBI NIH HHS U10 HL098096NIAID NIH HHS 1 R03 AI 101629-01NIAID NIH HHS 5 K23 AI 091691-02NIAID NIH HHS K23 AI091691NIAID NIH HHS R03 AI101629NIAID NIH HHS U19 AI095227PHS HHS U01-A1-100799
6 · The paper itself

Abstract

Children who begin wheezing during early childhood are frequently seen by health care providers in primary care, in hospitals, and in emergency departments, and by allergists and pulmonologists. When a young child, such as the 2 year-old patient presented here, is evaluated for wheezing, a frequent challenge for clinicians is to determine whether the symptoms represent transient, viral-induced wheezing or whether sufficient risk factors are present to suspect that the child may experience recurrent wheezing and develop asthma. Most factors that influence prognosis are not mutually exclusive, are interrelated (ie, cofactors), and often represent gene-environment interactions. Many of these risk factors have been, and continue to be, investigated in prospective studies to decipher their relative importance with the goal of developing new therapies and interventions in the future. The etiologies of wheezing in young children, diagnostic methods, treatment, prognostic factors, and potential targets for prevention of the development of asthma are discussed.

Indexed as

AsthmaRespiratory SoundsChild, PreschoolHumansMaleAsthmaChildhoodVirusWheezing

Identifiers

PMID25213046
PMCPMC4190166
OpenAlexW2156636860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.