SynthesisEuropean child & adolescent psychiatry2014
Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.
Synthesis in European child & adolescent psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- A meta-analysis of the relationship between bullying and non-suicidal self-injury among children and adolescents.Scientific reports · 2022Pooled it
- Pooled it
- Differentiating bipolar disorder from unipolar depression in youth: A systematic literature review of neuroimaging research studies.Psychiatry research. Neuroimaging · 2021Pooled it
- Supported employment: Meta-analysis and review of randomized controlled trials of individual placement and support.PloS one · 2019Pooled it
- Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder: A systematic review and meta-analysis.Medicine · 2018Pooled it
- DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder.International journal of molecular sciences · 2018Pooled it
- State-Specific Segmental Abnormalities of White Matter Structure and Function in Pediatric Bipolar Disorders.Bipolar disorders · 2026Article
- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.BMC psychiatry · 2024Article
- School Bullying, Bystander Behavior, and Mental Health among Adolescents: The Mediating Roles of Self-Efficacy and Coping Styles.Healthcare (Basel, Switzerland) · 2024Article
- Aberrant Hippocampal Development in Early-onset Mental Disorders and Promising Interventions: Evidence from a Translational Study.Neuroscience bulletin · 2024Article
- The unique contributions of depression and anxiety to suicidal ideation among Nigerian secondary school students: a cross-sectional survey.African health sciences · 2023Article
- Students are at risk? Elucidating the impact of health risks of COVID-19 on emotional exhaustion and academic performance: role of mindfulness and online interaction quality.Current psychology (New Brunswick, N.J.) · 2023Article
- Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume.Journal of affective disorders · 2023Article
- Testosterone and Suicidal Behavior in Bipolar Disorder.International journal of environmental research and public health · 2023Article
- Does the Brain Matter? Cortical Alterations in Pediatric Bipolar Disorder: A Critical Review of Structural and Functional Magnetic Resonance Studies.Current neuropharmacology · 2023Review
- Environmental Factors in the Etiology of Mental Disorders in the Czech Republic.Neuropsychiatric disease and treatment · 2023Article
- Determinants and predictors of mental health during and after COVID-19 lockdown among university students in Malaysia.PloS one · 2023Observational
- Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric bipolar disorder (BD) and unipolar disorder (UD) share common symptomatic and functional impairments. Various brain imaging techniques have been used to investigate the integrity of brain white matter (WM) and gray matter (GM) in these disorders. Despite promising preliminary findings, it is still unclear whether these alterations may be considered as common trait markers or may be used to distinguish BD from UD. A systematic literature search of studies between 1980 and September 2013 which reported WM/GM changes in pediatric and adolescent BD/UD, as detected by diffusion tensor imaging and voxel-based analysis was conducted. Of the 34 articles judged as eligible, 17 fulfilled our inclusion criteria and were finally retained in this review. More abnormalities have been documented in the brains of children and adolescents with BD than UD. Reductions in the volume of basal ganglia and the hippocampus appeared more specific for pediatric UD, whereas reduced corpus callosum volume and increased rates of deep WM hyperintensities were more specific for pediatric BD. Seminal papers failed to address the possibility that the differences between unipolar and bipolar samples might be related to illness severity, medication status, comorbidity or diagnosis. UD and BD present both shared and distinctive impairments in the WM and GM compartments. More WM abnormalities have been reported in children and adolescents with bipolar disease than in those with unipolar disease, maybe as a result of a low number of DTI studies in pediatric UD. Future longitudinal studies should investigate whether neurodevelopmental changes are diagnosis-specific.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.