ArticleAngewandte Chemie (International ed. in English)2014
Chemical probes for the functionalization of polyketide intermediates.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Enzymology of assembly line synthesis by modular polyketide synthases.Nature chemical biology · 2023Review
- Bioorthogonal Reactions of Triarylphosphines and Related Analogues.Chemical reviews · 2021Review
- Cyclobutanone Inhibitor of Cobalt-Functionalized Metallo-γ-Lactonase AiiA with Cyclobutanone Ring Opening in the Active Site.ACS omega · 2021Article
- A Straightforward Synthesis of Polyketides via Ester Dienolate Matteson Homologation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Optimizing a Fed-Batch High-Density Fermentation Process for Medium Chain-Length Poly(3-Hydroxyalkanoates) inFrontiers in bioengineering and biotechnology · 2021Article
- Article
- Anti-Foc RT4 Activity of a Newly IsolatedFrontiers in microbiology · 2020Article
- A Photoactivatable Small-Molecule Probe for the In Vivo Capture of Polyketide Intermediates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- A Light-Activated Acyl Carrier Protein "Trap" for Intermediate Capture in Type II Iterative Polyketide Biocatalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis.Nature catalysis · 2019Article
- Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.Natural product reports · 2018Review
- Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Synthetic Biology of Natural Products.Cold Spring Harbor perspectives in biology · 2016Review
- Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly.Chemical communications (Cambridge, England) · 2016Review
- Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Angewandte Chemie (International ed. in English) · 2016Article
- Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2016Article
- Chemical biology: biosynthetic interceptors.Nature chemistry · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyketide derivatives, including novel putative lasalocid A derivatives characterized by variable aryl ketone moieties and linear polyketide chains (bearing alkyne/azide handles and fluorine) flanking the polyether scaffold. By providing direct information on microorganism tolerance and enzyme processing of unnatural malonyl-ACP analogues, as well as on the amenability of unnatural polyketides to further structural modifications, the chemical probes constitute invaluable tools for the development of novel mutasynthesis and synthetic biology.
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Registered trials
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