ArticleCurrent microbiology2015
GABA accumulation in response to different nitrogenous compounds in unicellular cyanobacterium Synechocystis sp. PCC 6803.
Article in Current microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 20 citations in OpenAlex.
- A Non-functional γ-Aminobutyric Acid Shunt Pathway in CyanobacteriumInternational journal of molecular sciences · 2023Article
- Heterologous Expression of Ethanol Synthesis Pathway in Glycogen DeficientFrontiers in plant science · 2020Article
- Disruption of cyanobacterial γ-aminobutyric acid shunt pathway reduces metabolites levels in tricarboxylic acid cycle, but enhances pyruvate and poly(3-hydroxybutyrate) accumulation.Scientific reports · 2019Article
- Day and Night: Metabolic Profiles and Evolutionary Relationships of Six Axenic Non-Marine Cyanobacteria.Genome biology and evolution · 2019Article
- Spermidine Synthase is Required for Growth of Synechococcus sp. PCC 7942 Under Osmotic Stress.Current microbiology · 2016Article
- Highly Selective Bioconversion of Ginsenoside Rb1 to Compound K by the Mycelium of Cordyceps sinensis under Optimized Conditions.Molecules (Basel, Switzerland) · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
GABA accumulation and glutamate decarboxylase (GAD) activity, the principal enzyme involved in GABA formation, was investigated in cyanobacterium Synechocystis sp. PCC 6803 wild-type (WT) and gad knockout mutant strains grown in medium containing different nitrogenous compounds. Nitrate was the best nitrogen source for GAD activity and GABA accumulation followed by nitrite, ammonium, and urea. An increase in the accumulation of GABA was observed in WT and mutant cells grown for 24 h in medium supplemented with 0.5 mM putrescine or spermidine with a parallel increase in GAD activity. The mutant could not accumulate GABA at all the conditions tested except when supplemented with putrescine or spermidine, where high GABA levels were observed in both WT and mutant strains. Glutamate supplementation up to 10 mM for 24 h resulted in a significant increase in both GAD activity and GABA content. Overall results suggested that optimization of nitrogen source and nitrogenous compounds supplementation was effective for the enhancement of GABA accumulation in Synechocystis.
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