ReviewSeminars in immunopathology2014
Use of animal models in elucidating disease pathogenesis in IBD.
Review in Seminars in immunopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Trial
- The global stress response regulatorGut microbes · 2025Article
- The role of Raptor in lymphocytes differentiation and function.Frontiers in immunology · 2023Review
- The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies.Annals of the rheumatic diseases · 2019Review
- Extracts fromOncotarget · 2017Article
- TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis.Cell death & disease · 2017Article
- A vitamin D receptor agonist converts CD4+ T cells to Foxp3+ regulatory T cells in patients with ulcerative colitis.Oncotarget · 2017Article
- Anti-inflammatory effect of Chang-An-Shuan on TNBS-induced experimental colitis in rats.BMC complementary and alternative medicine · 2017Article
- Mouse Model of Reversible Intestinal Inflammation.Bio-protocol · 2017Article
- Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.United European gastroenterology journal · 2016Review
- CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis.Mucosal immunology · 2016Article
- Article
- Spontaneous and transgenic rodent models of inflammatory bowel disease.Laboratory animal research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Inflammatory bowel diseases (IBD) are a collection of diseases characterized by chronic gastrointestinal inflammation resulting from an exuberant immune response to commensal flora in genetically susceptible individuals. Rapid advances in the field of genomics have resulted in the identification of at least 163 loci that contribute susceptibility to both Crohn's disease (CD) and ulcerative colitis (UC). Similar to other complex diseases, however, the "curse of missing heritability" remains a significant concern in understanding the mechanisms underlying IBD. While genetic discoveries, to date, only account for 7-14% of disease variance for IBD, studies have increasingly demonstrated a role for environmental factors in disease pathogenesis. Furthermore, the use of animal models of IBD has led to a greater understanding of disease pathogenesis implicating various aspects of the innate immune response including the bacterial, fungal, and viral microbiome and adaptive immune response such as the interleukin (IL)-23/IL-17 pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.