SynthesisArchives of women's mental health2014
Neurodevelopmental outcome for offspring of women treated for antenatal depression: a systematic review.
Synthesis in Archives of women's mental health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of maternal antidepressant use in pregnancy and short- and long-term offspring's outcomes.Archives of women's mental health · 2018Pooled it
- Identifying the women at risk of antenatal anxiety and depression: A systematic review.Journal of affective disorders · 2016Pooled it
- Yoga for prenatal depression: a systematic review and meta-analysis.BMC psychiatry · 2015Pooled it
- Optimising antidepressant therapy in pregnancy: a perspective on therapeutic drug monitoring and model-informed precision dosing.Frontiers in pharmacology · 2026Article
- Depressive, anxiety symptoms and their co-occurrence among women seeking antenatal care in Bangladesh.Scientific reports · 2025Article
- Relationship between depressive symptoms and sleep quality and cognitive inhibition ability in prenatal pregnant women.BMC psychiatry · 2023Article
- Urinary metabolites as a predictive marker for perinatal depression: A secondary analysis of the mothers, Omega-3 & Mental Health Study.Psychiatry research communications · 2022Article
- Effects, Side Effects and Contraindications of Relaxation Massage during Pregnancy: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2021Review
- Anxiety and depression in reproductive age women with rheumatic diseases.Rheumatology international · 2020Observational
- Intergenerational transmission of depression: clinical observations and molecular mechanisms.Molecular psychiatry · 2019Review
- Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood - Depression (PRAM-D) Study.Psychoneuroendocrinology · 2018Article
- Predicting Escitalopram Exposure to Breastfeeding Infants: Integrating Analytical and In Silico Techniques.Clinical pharmacokinetics · 2018Article
- Recent advances in understanding maternal perinatal mood disorders.F1000Research · 2017Review
- Use of Antidepressants During Pregnancy?: What to Consider when Weighing Treatment with Antidepressants Against Untreated Depression.Maternal and child health journal · 2016Review
- Atropinic burden of drugs during pregnancy and psychological development of children: a cohort study in the EFEMERIS database.British journal of clinical pharmacology · 2016Article
- The Neurobiological Impact of Postpartum Maternal Depression: Prevention and Intervention Approaches.Child and adolescent psychiatric clinics of North America · 2016Review
- Perinatal Anxiety and Depression in Minority Women.MCN. The American journal of maternal child nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The aim of this systematic review is to appraise existing literature on the effects of treatments for antenatal depression on the neurodevelopment outcomes of the offspring. We conducted a systematic review of the literature to identify studies on different kinds of treatments for antenatal depression (antidepressants and alternative therapies) and their effects on infants' neurodevelopment. After reading the title, abstract, or full text and applying exclusion criteria, a total of 22 papers were selected. Nineteen papers studied the effects of antidepressant drugs, one on docosahexanoic acid (DHA) (fish oil capsules) and two on massage therapy; however, no studies used a randomized controlled design, and in most studies, the control group comprise healthy women not exposed to depression. Comparisons between newborns exposed to antidepressants in utero with those not exposed showed significant differences in a wide range of neurobehavioral outcomes, although in many cases, these symptoms were transient. Two studies found a slight delay in psychomotor development, and one study found a delay in mental development. Alternative therapies may have some benefits on neurodevelopmental outcomes. Our review suggests that antidepressant treatment may be associated with some neurodevelopmental changes, but we cannot exclude that some of these effects may be due to depression per se.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.