ArticleHistochemistry and cell biology2015
Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels.
Article in Histochemistry and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Placental contractions in uncomplicated pregnancies.PloS one · 2026Observational
- Localization of Catecholaminergic Neurofibers in Pregnant Cervix as a Possible Myometrial Pacemaker.International journal of molecular sciences · 2024Article
- Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis.Cell and tissue research · 2024Article
- Vascular endothelial growth factor facilitates the effects of telocytes on tumor cell proliferation and migration.Frontiers in cell and developmental biology · 2024Article
- Pathophysiological Implications of Interstitial Cajal-like Cells (ICC-like) in Uterus: A Comparative Study with Gastrointestinal ICCs.Current issues in molecular biology · 2023Review
- Estradiol enhances T-type calcium channel activation in human myometrium telocytes.The Journal of reproduction and development · 2023Article
- Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications.Life (Basel, Switzerland) · 2022Review
- Telocytes in the human ascending aorta: Characterization and exosome-related KLF-4/VEGF-A expression.Journal of cellular and molecular medicine · 2021Article
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells.International journal of molecular sciences · 2020Article
- Simulation and Modeling of Telocytes Behavior in Signaling and Intercellular Communication Processes.International journal of molecular sciences · 2020Article
- Article
- Reappraising the microscopic anatomy of human testis: identification of telocyte networks in the peritubular and intertubular stromal space.Scientific reports · 2018Article
- Identification of Myocardial Telocytes and Bone Marrow Mesenchymal Stem Cells in Mice.Cell transplantation · 2018Article
- Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.International journal of molecular sciences · 2018Article
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia.Scientific reports · 2018Article
- Calcium Signaling in Interstitial Cells: Focus on Telocytes.International journal of molecular sciences · 2017Review
- Telocytes in female reproductive system (human and animal).Journal of cellular and molecular medicine · 2016Review
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, telocytes (TCs) were described as a new cell type in the interstitial space of many organs, including myometrium. TCs are cells with very long, distinctive extensions named telopodes (Tps). It is suggested that TCs play a major role in intercellular signaling, as well as in morphogenesis, especially in morphogenetic bioelectrical signaling. However, TC plasma membrane is yet unexplored regarding the presence and activity of ion channels and pumps. Here, we used a combination of in vitro immunofluorescence and patch-clamp technique to characterize T-type calcium channels in TCs. Myometrial TCs were identified in cell culture (non-pregnant and pregnant myometrium) as cells having very long Tps and which were positive for CD34 and platelet-derived growth factor receptor-α. Immunofluorescence analysis of the subfamily of T-type (transient) calcium channels CaV3.1 and CaV3.2 presence revealed the expression of these ion channels on the cell body and Tps of non-pregnant and pregnant myometrium TCs. The expression in TCs from the non-pregnant myometrium is less intense, being confined to the cell body for CaV3.2, while CaV3.1 was expressed both on the cell body and in Tps. Moreover, the presence of T-type calcium channels in TCs from non-pregnant myometrium is also confirmed by applying brief ramp depolarization protocols. In conclusion, our results show that T-type calcium channels are present in TCs from human myometrium and could participate in the generation of endogenous bioelectric signals responsible for the regulation of the surrounding cell behavior, during pregnancy and labor.
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