ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
The role of genetics in estrogen responses: a critical piece of an intricate puzzle.
Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The Effect of Hormonal Contraceptive Use on Skeletal Muscle Hypertrophy, Power and Strength Adaptations to Resistance Exercise Training: A Systematic Review and Multilevel Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- PCOS-like phenotype in rats after intrauterine EV exposure: puberty and adulthood.Endocrine connections · 2026Article
- Concise Synthesis of Naphthalene-Based 14-Aza-12-Oxasteroids.Molecules (Basel, Switzerland) · 2025Article
- The multi-faceted nature of age-associated osteoporosis.Bone reports · 2024Review
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- The Intergeneration Long-Lasting Consequences of Pre-Conceptional Exposure to Sofosbuvir on the Ovarian Tissues of F1 Offspring: Experimental Study on Rats.International journal of molecular sciences · 2023Article
- Progress in Research on Key Factors Regulating Lactation Initiation in the Mammary Glands of Dairy Cows.Genes · 2023Review
- Pharmacogenomics and health disparities, are we helping?Frontiers in genetics · 2023Review
- Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.iScience · 2022Article
- Associations between testosterone, estradiol, and androgen receptor genotype with amygdala subregions in adolescents.Psychoneuroendocrinology · 2022Article
- How nonshared environmental factors come to correlate with heredity.Development and psychopathology · 2022Article
- Yin Huo Tang, a traditional Chinese herbal formula, relives ovariectomy and empty bottle stimulation-induced menopause-like symptoms in mice.Frontiers in endocrinology · 2022Article
- Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice.Toxicological research · 2022Article
- An approach to uncover the relationship between 17b-estradiol and ESR1/ESR2 ratio in the regulation of canine corpus luteum.Frontiers in veterinary science · 2022Article
- Bisphenol B Exposure Disrupts Mouse Oocyte Meiotic MaturationFrontiers in cell and developmental biology · 2020Article
- Genetic variation in sensitivity to estrogens and breast cancer risk.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary.Scientific reports · 2017Article
- What's new in estrogen receptor action in the female reproductive tract.Journal of molecular endocrinology · 2016Review
- Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth. They are mainly known for their roles in reproductive tissues--specifically, 17β-estradiol (E2), the primary estrogen, which is secreted by the ovaries and induces cellular proliferation and growth of the uterus and mammary glands. In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues. The responsiveness of various tissues to estrogen is genetically controlled, with marked quantitative variation observed across multiple species, including humans. This variation presents both researchers and clinicians with a veritable physiological puzzle, the pieces of which--many of them unknown--are complex and difficult to fit together. Although genetics is known to play a major role in determining sensitivity to estrogens, there are other factors, including parent of origin and the maternal environment, that are intimately linked to heritable phenotypes but do not represent genotype, per se. The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.