ArticleSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde2014
Evaluation of adherence to national treatment guidelines among tuberculosis patients in three provinces of South Africa.
Article in South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- A systematic review of risk factors for mortality among tuberculosis patients in South Africa.Systematic reviews · 2023Pooled it
- Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis.PloS one · 2019Pooled it
- Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies.PLoS medicine · 2018Pooled it
- Trial
- Integrating narrative and bibliometric approaches to examine factors and impacts of tuberculosis treatment non-compliance.Multidisciplinary respiratory medicine · 2025Article
- Virtual nurse support to enhance antipsychotic adherence in schizophrenia: A South African perspective.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Article
- Treatment of drug-susceptible tuberculosis among people living with human immunodeficiency virus infection: an update.Current opinion in HIV and AIDS · 2018Review
- The rise and fall of mortality inequality in South Africa in the HIV era.SSM - population health · 2018Article
- A model of population dynamics of TB in a prison system and application to South Africa.BMC research notes · 2017Article
- Risk factors for tuberculosis smear non-conversion in Eden district, Western Cape, South Africa, 2007-2013: a retrospective cohort study.BMC infectious diseases · 2016Article
- Adherence to Anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia.BMC research notes · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
settingStandardised tuberculosis (TB) treatment through directly observed therapy (DOT) is available in South Africa, but the level of adherence to standardised TB treatment and its impact on treatment outcomes is unknown.
objectivesTo describe adherence to standardised TB treatment and provision of DOT, and analyse its impact on treatment outcome.
methodsWe utilised data collected for an evaluation of the South African national TB surveillance system. A treatment regimen was considered appropriate if based on national treatment guidelines. Multivariate log-binomial regression was used to evaluate the association between treatment regimens, including DOT provision, and treatment outcome.
resultsOf 1 339 TB cases in the parent evaluation, 598 (44.7%) were excluded from analysis owing to missing outcome or treatment information. The majority (697, 94.1%) of the remaining 741 patients received an appropriate TB regimen. Almost all patients (717, 96.8%) received DOT, 443 (59.8%) throughout the treatment course and 274 (37.0%) during the intensive (256, 34.6%) or continuation (18, 2.4%) phase. Independent predictors of poor outcome were partial DOT (adjusted risk ratio (aRR) 3.1, 95% confidence interval (CI) 2.2 - 4.3) and previous treatment default (aRR 2.3, 95% CI 1.1 - 4.8).
conclusionPatients who received incomplete DOT or had a history of defaulting from TB treatment had an increased risk of poor outcomes.
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