ReviewMissouri medicine
Beta blocker eye drops for treatment of acute migraine.
Review in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Migraine relief in 20 minutes using eyedrops?The Journal of family practice · 2022Trial
- Timolol Eyedrops in the Treatment of Acute Migraine Attacks: A Randomized Crossover Study.JAMA neurology · 2018Trial
- Answering the Call: A Prospective Look at the Role of Timolol Eye Drops in the Treatment of Acute Migraine Attacks.Missouri medicineTrial
- Exploring the pH-Responsive Interaction of β-Blocker Drug Propranolol with Biomimetic Micellar Media: Fluorescence and Electronic Absorption Studies.Journal of fluorescence · 2024Article
- A Case of Recurrent Painful Ophthalmoplegic Neuropathy Successfully Treated with Beta-blocker Eye Drop Instillation.Neuro-ophthalmology (Aeolus Press) · 2021Article
- A Randomized, Double-Blinded, Placebo-Controlled, Cross Over Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine.Kansas journal of medicine · 2020Article
- Nasally Delivered 0.5% Timolol Beta Blocker Successfully Treats Acute Migraines in a Referral Headache Clinic: A Case Series.Missouri medicineArticle
- CRITIQUE: Beta Blocker Nasal Spray for Actue Migraine.Missouri medicineArticle
- Article
- Topical Beta Blockers for the Treatment of Acute Migraines in 2019.Missouri medicineArticle
- Mixing It Up: The Art and Science of Compounding Pharmacy.Missouri medicineArticle
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report seven cases of successful treatment of acute migraine symptoms using beta blocker eye drops. The literature on beta blockers for acute migraine is reviewed. Oral beta blocker medication is not effective for acute migraine treatment. This is likely due to a relatively slow rate of achieving therapeutic plasma levels when taken orally. Topical beta blocker eye drops achieve therapeutic plasma levels within minutes of ocular administration which may explain their apparent effectiveness in relief of acute migraine symptoms.
Indexed as
Identifiers
25211851PMC6179466W2400804915What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.