Evidence map›Paper›PMID 25211636›Full record

ReviewBiomolecules2014

The 26S proteasome and initiation of gene transcription.

Geetha Durairaj, Peter Kaiser

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Innate immunity in C. elegans.Current topics in developmental biology · 2021
    Review
  8. Article
  9. Tuning up Transcription Factors for Therapy.Molecules (Basel, Switzerland) · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity.International journal of molecular sciences · 2019
    Review
  14. Proteasomes tether to two distinct sites at the nuclear pore complex.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  15. Article
  16. Article
  17. The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention.International journal of molecular sciences · 2017
    Review
  18. The Regulation of Synaptic Protein Turnover.The Journal of biological chemistry · 2015
    Review
  19. Article
  20. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Geetha DurairajDepartment of Biological Chemistry, University of California, Irvine, CA 92697, USA. gduraira@uci.edu.
Peter KaiserDepartment of Biological Chemistry, University of California, Irvine, CA 92697, USA. pkaiser@uci.edu.
University of California, Irvine · US

Funding

Ubiquitin SignalingR01GM066164 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KAISER, PETER · 2002 to 2022
$7.4M
A Functional Census of p53 Cancer and Suppressor MutantsR01CA112560 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KAISER, PETER, LATHROP, RICHARD H · 2005 to 2013
$3.2M
Regulation by Proteolysis-Independent UbiquitinationR56GM066164 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KAISER, PETER · 2007 to 2007
$265k
NCI NIH HHS CA-112560NCI NIH HHS R01 CA112560NIGMS NIH HHS GM-066164NIGMS NIH HHS R01 GM066164NIGMS NIH HHS R56 GM066164
6 · The paper itself

Abstract

Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control. In recent years, growing evidence has highlighted the 26S proteasome as an important contributor to the regulation of transcription initiation. Well known for its role in protein destruction, its contribution to protein synthesis was initially viewed with skepticism. However, studies over the past several years have established the proteasome as an important component of transcription initiation through proteolytic and non-proteolytic activities. In this review, we discuss findings made so far in understanding the connections between transcription initiation and the 26S proteasome complex.

Indexed as

Transcription Initiation, GeneticHumansProteasome Endopeptidase ComplexTranscriptional ActivationATP dependent 26S proteaseProteasome Endopeptidase Complex

Identifiers

PMID25211636
PMCPMC4192674
OpenAlexW1974350858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.