ArticleNature protocols2014
Juxtacellular recording and morphological identification of single neurons in freely moving rats.
Article in Nature protocols, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A method to analyze gene expression profiles from hippocampal neurons electrophysiologically recordedFrontiers in neuroscience · 2024Article
- Opto-juxtacellular interrogation of neural circuits in freely moving mice.Nature protocols · 2023Review
- Article
- Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know.Frontiers in cellular neuroscience · 2021Review
- Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Probing Cortical Activity During Head-Fixed Behavior.Frontiers in molecular neuroscience · 2020Article
- Burst Firing and Spatial Coding in Subicular Principal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Testing the Efficacy of Single-Cell Stimulation in Biasing Presubicular Head Direction Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Temporally precise control of single-neuron spiking by juxtacellular nanostimulation.Journal of neurophysiology · 2017Article
- Article
- Vibrissa motor cortex activity suppresses contralateral whisking behavior.Nature neuroscience · 2017Article
- Article
- The enigmatic mossy cell of the dentate gyrus.Nature reviews. Neuroscience · 2016Review
- Cell Type-Specific Differences in Spike Timing and Spike Shape in the Rat Parasubiculum and Superficial Medial Entorhinal Cortex.Cell reports · 2016Article
- Article
- Functional Architecture of the Rat Parasubiculum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Head-Directional Tuning and Theta Modulation of Anatomically Identified Neurons in the Presubiculum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Anatomical Organization and Spatiotemporal Firing Patterns of Layer 3 Neurons in the Rat Medial Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- An optogenetics- and imaging-assisted simultaneous multiple patch-clamp recording system for decoding complex neural circuits.Nature protocols · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that neural circuits consist of a great diversity of cell types, but very little is known about how neuronal diversity contributes to cognition and behavior. One approach to addressing this problem is to directly link cellular diversity to neuronal activity recorded in vivo in behaving animals. Here we describe the technical procedures for obtaining juxtacellular recordings from single neurons in trained rats engaged in exploratory behavior. The recorded neurons can be labeled to allow subsequent anatomical identification. In its current format, the protocol can be used for resolving the cellular identity of spatially modulated neurons (i.e., head-direction cells and grid cells), which form the basis of the animal's internal representation of space, but this approach can easily be extended to other unrestrained behaviors. The procedures described here, from the beginning of animal training to the histological processing of brain sections, can be completed in ≈ 3-4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.