ArticlePLoS genetics2014
Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 123 citations in OpenAlex.
- H3K4 Methylation Readers in Plants: Recognition Mechanisms and Biological Functions.International journal of molecular sciences · 2026Review
- Dynamic regulatory mechanisms of histone methylation in plant development and environmental adaptation.Horticulture research · 2026Article
- Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience.The New phytologist · 2026Review
- Arabidopsis INHIBITOR OF GROWTH 2 promotes flowering by regulating NuA4-dependent H4 acetylation levels at FT and SOC1.Plant physiology · 2025Article
- A pair of readers of histone H3K4 methylation recruit Polycomb repressive complex 2 to regulate photoperiodic flowering.Nature communications · 2025Article
- Abscisic acid and GIGANTEA signalling converge to regulate the recruitment of CONSTANS to the FT promoter and activate floral transition.Journal of experimental botany · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- More than flowering: CONSTANS plays multifaceted roles in plant development and stress responses.Journal of integrative plant biology · 2025Review
- Article
- Prediction of plant complex traits via integration of multi-omics data.Nature communications · 2024Article
- Epigenetic regulation of photoperiodic flowering in plants.The plant genome · 2023Review
- Rice OsMRG702 and Its Partner OsMRGBP Control Flowering Time through H4 Acetylation.International journal of molecular sciences · 2023Article
- Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.Plant communications · 2023Review
- PMT6 Is Required for SWC4 in Positively Modulating Pepper Thermotolerance.International journal of molecular sciences · 2023Article
- Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time.The Plant cell · 2022Article
- The roles of epigenetic modifications in the regulation of auxin biosynthesis.Frontiers in plant science · 2022Review
- Molecular Genetic Understanding of Photoperiodic Regulation of Flowering Time inInternational journal of molecular sciences · 2021Review
- Leveraging histone modifications to improve genome annotations.G3 (Bethesda, Md.) · 2021Article
- A MRG-operated chromatin switch at SOC1 attenuates abiotic stress responses during the floral transition.Plant physiology · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Day-length is important for regulating the transition to reproductive development (flowering) in plants. In the model plant Arabidopsis thaliana, the transcription factor CONSTANS (CO) promotes expression of the florigen FLOWERING LOCUS T (FT), constituting a key flowering pathway under long-day photoperiods. Recent studies have revealed that FT expression is regulated by changes of histone modification marks of the FT chromatin, but the epigenetic regulators that directly interact with the CO protein have not been identified. Here, we show that the Arabidopsis Morf Related Gene (MRG) group proteins MRG1 and MRG2 act as H3K4me3/H3K36me3 readers and physically interact with CO to activate FT expression. In vitro binding analyses indicated that the chromodomains of MRG1 and MRG2 preferentially bind H3K4me3/H3K36me3 peptides. The mrg1 mrg2 double mutant exhibits reduced mRNA levels of FT, but not of CO, and shows a late-flowering phenotype under the long-day but not short-day photoperiod growth conditions. MRG2 associates with the chromatin of FT promoter in a way dependent of both CO and H3K4me3/H3K36me3. Vice versa, loss of MRG1 and MRG2 also impairs CO binding at the FT promoter. Crystal structure analyses of MRG2 bound with H3K4me3/H3K36me3 peptides together with mutagenesis analysis in planta further demonstrated that MRG2 function relies on its H3K4me3/H3K36me3-binding activity. Collectively, our results unravel a novel chromatin regulatory mechanism, linking functions of MRG1 and MRG2 proteins, H3K4/H3K36 methylations, and CO in FT activation in the photoperiodic regulation of flowering time in plants.
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