ArticleJournal of perinatology : official journal of the California Perinatal Association2015
Spiramycin/cotrimoxazole versus pyrimethamine/sulfonamide and spiramycin alone for the treatment of toxoplasmosis in pregnancy.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- [Use of antiparasitic drugs in the prevention of congenital toxoplasmosis: systematic review and meta-analysis].Medecine tropicale et sante internationale · 2025Pooled it
- Prophylaxis of human toxoplasmosis: a systematic review.Pathogens and global health · 2017Pooled it
- A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans.PloS one · 2015Pooled it
- Imidazopyridine derivatives as promising anti-RSC advances · 2026Article
- Inhibitors of the FASII Metabolic Pathway inMicroorganisms · 2026Review
- Treatment Protocols for Gestational and Congenital Toxoplasmosis: A Systematic Review and Meta-Analysis.Microorganisms · 2025Review
- Prophylactic Effect of Microwave Radiation onJournal of parasitology research · 2025Article
- Article
- In defense of children's brain: reshuffling the laboratory toolbox for the diagnosis of congenital toxoplasmosis.Journal of clinical microbiology · 2024Article
- Essential oil of oregano (Origanum vulgare L.) reduces infection and proliferation of Toxoplasma gondii in BeWo cells with induction of autophagy and death of tachyzoites through a mechanism similar to necrosis.Parasitology research · 2024Article
- Considerations in the management of ocular toxoplasmosis in pregnancy: a review of literature.Eye (London, England) · 2024Review
- Toxoplasmosis Infection during Pregnancy.Tropical medicine and infectious disease · 2022Review
- From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review.Children (Basel, Switzerland) · 2022Review
- Congenital toxoplasmosis: Should we still care about screening?Food and waterborne parasitology · 2022Article
- The powerful synergistic effect of spiramycin/propolis loaded chitosan/alginate nanoparticles on acute murine toxoplasmosis.PLoS neglected tropical diseases · 2022Article
- Remarkable histopathological improvement of experimental toxoplasmosis after receiving spiramycin-chitosan nanoparticles formulation.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Global Lysine Crotonylation and 2-Hydroxyisobutyrylation in Phenotypically DifferentMolecular & cellular proteomics : MCP · 2019Article
- Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.Clinical microbiology reviews · 2018Review
- Analysis of Anti-toxoplasma Immunoglobulin G and Immunoglobulin M Antibody Levels after Intervention withJournal of global infectious diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the effectiviness of spiramycin/cotrimoxazole (Sp/C) versus pyrimethamine/sulfonamide (Pyr/Sul) and spiramycin alone (Spy) on mother-to-child transmission of toxoplasmosis infection in pregnancy. STUDY
designRetrospective study of pregnant women evaluated for suspected toxoplasmosis between 1992 and 2011.
resultA total of 120 mothers and their 123 newborns were included. Prenatal treatment consisted of spiramycin in 43 mothers (35%), spiramycin/cotrimoxazole in 70 (56.9%) and pyrimethamine/sulfonamide in 10 (8.1%). A trend toward reduction in toxoplasmosis transmission was found when Sp/C was compared with Pyr/Sul and particularly with Spy alone (P=0.014). In particular, Spy increased the risk of congenital infection when compared with Sp/C (odds ratio (OR) 4.368; 95% CI: 1.253 to 15.219), but there was no significant reduction when Sp/C was compared with Pyr/Sul (OR 1.83; 95% CI: 0.184 to 18.274).
conclusionThe treatment based on Sp/C has significant efficacy in reducing maternal-fetal transmission of Toxoplasma gondii when compared with Pyr/Sul and particularly to Spy. Randomized controlled trials would be required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.