ArticlePloS one2014
1H-NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Metabolomics after trauma in experimental models- a systematic review.Langenbeck's archives of surgery · 2026Pooled it
- Formulation insights into competitive binding of NJournal of pharmaceutical and biomedical analysis · 2025Article
- Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics-A Preliminary Study.Metabolites · 2020Article
- Mechanisms of innate preconditioning towards ischemia/anoxia tolerance: Lessons from mammalian hibernators.Conditioning medicine · 2019Article
- Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel.Journal of proteome research · 2019Article
- All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.The journal of trauma and acute care surgery · 2018Article
- Negative Energy Balance Does Not Alter Fat-Free Mass During the Yukon Arctic Ultra-The Longest and the Coldest Ultramarathon.Frontiers in physiology · 2018Article
- Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux.Journal of neurochemistry · 2017Article
- Metabolic Responses to the Yukon Arctic Ultra: Longest and Coldest in the World.Medicine and science in sports and exercise · 2017Article
- Article
- The effects of hibernation and forced disuse (neurectomy) on bone properties in arctic ground squirrels.Physiological reports · 2016Article
- Ischemia/reperfusion injury resistance in hibernators is more than an effect of reduced body temperature or winter season.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHemorrhagic shock (HS) following trauma is a leading cause of death among persons under the age of 40. During HS the body undergoes systemic warm ischemia followed by reperfusion during medical intervention. Ischemia/reperfusion (I/R) results in a disruption of cellular metabolic processes that ultimately lead to tissue and organ dysfunction or failure. Resistance to I/R injury is a characteristic of hibernating mammals. The present study sought to identify circulating metabolites in the rat as biomarkers for metabolic alterations associated with poor outcome after HS. Arctic ground squirrels (AGS), a hibernating species that resists I/R injury independent of decreased body temperature (warm I/R), was used as a negative control. METHODOLOGY/PRINCIPAL
findingsMale Sprague-Dawley rats and AGS were subject to HS by withdrawing blood to a mean arterial pressure (MAP) of 35 mmHg and maintaining the low MAP for 20 min before reperfusing with Ringers. The animals' temperature was maintained at 37 ± 0.5 °C for the duration of the experiment. Plasma samples were taken immediately before hemorrhage and three hours after reperfusion. Hydrophilic and lipid metabolites from plasma were then analyzed via 1H-NMR from unprocessed plasma and lipid extracts, respectively. Rats, susceptible to I/R injury, had a qualitative shift in their hydrophilic metabolic fingerprint including differential activation of glucose and anaerobic metabolism and had alterations in several metabolites during I/R indicative of metabolic adjustments and organ damage. In contrast, I/R injury resistant AGS, regardless of season or body temperature, maintained a stable metabolic homeostasis revealed by a qualitative 1H-NMR metabolic profile with few changes in quantified metabolites during HS-induced global I/R. CONCLUSIONS/SIGNIFICANCE: An increase in circulating metabolites indicative of anaerobic metabolism and activation of glycolytic pathways is associated with poor prognosis after HS in rats. These same biomarkers are absent in AGS after HS with warm I/R.
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