ArticleEuropean journal of heart failure2014
Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort.
Article in European journal of heart failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910349 (Novel Cardiac Imaging Prognostic Markers of Clinical Outcome in Patients With Chronic Aortic Regurgitation - Echocardiography and Magnetic Resonance), which is not on this map. Cited by 138 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Cardiac Imaging Prognostic Markers of Clinical Outcome in Patients With Chronic Aortic Regurgitation - Echocardiography and Magnetic Resonance
Who cites it
138 citing papers in PubMed, 3 syntheses or guidelines pooled it, 257 citations in OpenAlex.
- Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: a systematic review.Journal of cancer survivorship : research and practice · 2022Pooled it
- Prognostic value of left ventricular global longitudinal strain in chronic kidney disease patients: a systematic review and meta-analysis.International urology and nephrology · 2020Pooled it
- Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis.Vascular health and risk management · 2019Pooled it
- Echocardiographic Parameters for Predicting Atrial Fibrillation Following Ischemic Stroke: The PER DIEM Echocardiography Substudy.Echocardiography (Mount Kisco, N.Y.) · 2026Trial
- The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease.Blood pressure monitoring · 2017Trial
- Fully Automated Evaluation of Left Ventricular Global Longitudinal Strain in Normal Hearts: An Assessment of Accuracy in the Pediatric Population.Pediatric cardiology · 2026Article
- Electro-Mechanical Cardiac Remodeling in Metabolic Syndrome: Association Between Frontal QRS-T Angle and Subclinical Left Ventricular Dysfunction Assessed by Four-Dimensional Echocardiography.Journal of clinical medicine · 2026Article
- Natriuretic peptides and cardiac troponins in hypertension and heart failure: A contemporary review of the evidence.Journal of human hypertension · 2026Review
- Associations of Integrated Left Ventricular Myocardial Strain Metrics and Incident Atrial Fibrillation.CJC open · 2026Article
- Association of PREVENT risk model with body fat distribution and subclinical left ventricular dysfunction.American journal of preventive cardiology · 2026Article
- Impact of coronary artery disease on systolic function in severe aortic stenosis-a multimodality imaging study.European heart journal. Imaging methods and practice · 2026Article
- High-Intensity Interval Training and Moderate-Intensity Continuous Training on Ventricular-Arterial Coupling (VAC) in Young Women With Obesity.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study.International journal of obesity (2005) · 2025Article
- Principal Strain Analysis for Early Detection of Radiation-Induced Cardiotoxicity in a Mouse Model.International journal of radiation oncology, biology, physics · 2025Article
- Association of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis.CJC open · 2025Article
- Article
- Role of Strain-Derived Echocardiography Modality in Risk Stratification of High-Risk-Feature Chronic Coronary Syndrome Patients.JACC. Case reports · 2025Article
- Assessment of left ventricular systolic function and pathological changes using layer-specific strain in rats with myocardial hypertrophy at various disease stages.The international journal of cardiovascular imaging · 2025Article
- Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Left Ventricular Systolic Function in Asymptomatic Men Aged 65-75 Years, Relation to Insulin Resistance and Pre-Diabetes: A DANCAVAS Cross-Sectional Sub-Study.Journal of cardiovascular development and disease · 2025Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
aimsGlobal longitudinal strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular systolic function at a stage when left ventricular ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of left ventricular systolic dysfunction (LVSD) assessed by echocardiographic speckle-tracking GLS in a community-based cohort. METHODS AND
resultsParticipants from the community-based prospective Northern Manhattan Study underwent two-dimensional transthoracic echocardiography as part of the Cardiovascular Abnormalities and Brain Lesions study. Left ventricular systolic function was assessed by LVEF and speckle-tracking GLS. Subjects were followed annually (mean = 4.8 ± 1.5 years) and incident vascular events (ischaemic stroke, myocardial infarction, and vascular death) were reviewed and adjudicated. Of the 708 study participants, 114 (16.1%) had abnormal GLS but normal LVEF (GLS-LVSD), 30 (4.2%) had abnormal LVEF (LVEF-LVSD), and 564 (79.7%) had normal GLS and LVEF (no-LVSD). In multivariate analysis, risk of events was significantly greater in GLS-LVSD [adjusted hazard ratio (HR) = 2.39, 95% confidence interval (CI) = 1.20-4.77] and in LVEF-LVSD (adjusted HR = 3.51, 95% CI = 1.25-9.88) compared with no-LVSD. Among participants with normal LVEF, lower GLS was significantly associated with events (adjusted HR/unit decrease = 1.15, 95% CI = 1.03-1.28) whereas LVEF was not (adjusted HR/unit decrease = 1.01, 95% CI = 0.94-1.07). The GLS prognostic value was incremental to risk factors and LVEF both in the overall population (chi-square change = 7.406, P = 0.006) and in participants with normal LVEF (chi-square change = 6.357, P = 0.012).
conclusionIn a community-based cohort, GLS-LVSD was four times more frequent than LVEF-LVSD. GLS-LVSD was a powerful and independent predictor of cardiovascular events. Left ventricular function assessment by GLS may improve cardiovascular risk stratification in subjects with normal LVEF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.