ArticlePLoS genetics2014
Causal variation in yeast sporulation tends to reside in a pathway bottleneck.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genome-scale metabolic modelling identifies reactions mediated by SNP-SNP interactions associated with yeast sporulation.NPJ systems biology and applications · 2025Article
- Creeping yeast: a simple, cheap and robust protocol for the identification of mating type in Saccharomyces cerevisiae.FEMS yeast research · 2022Article
- Infection by dsRNA viruses is associated with enhanced sporulation efficiency inEcology and evolution · 2022Article
- Crossbreeding of Yeasts Domesticated for Fermentation: Infertility Challenges.International journal of molecular sciences · 2020Review
- Article
- Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes.PLoS genetics · 2017Article
- Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.G3 (Bethesda, Md.) · 2016Article
- Population perspectives on functional genomic variation in yeast.Briefings in functional genomics · 2016Review
- Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype.PLoS genetics · 2015Article
- Differential regulation of antagonistic pleiotropy in synthetic and natural populations suggests its role in adaptation.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been extensive debate over whether certain classes of genes are more likely than others to contain the causal variants responsible for phenotypic differences in complex traits between individuals. One hypothesis states that input/output genes positioned in signal transduction bottlenecks are more likely than other genes to contain causal natural variation. The IME1 gene resides at such a signaling bottleneck in the yeast sporulation pathway, suggesting that it may be more likely to contain causal variation than other genes in the sporulation pathway. Through crosses between natural isolates of yeast, we demonstrate that the specific causal nucleotides responsible for differences in sporulation efficiencies reside not only in IME1 but also in the genes that surround IME1 in the signaling pathway, including RME1, RSF1, RIM15, and RIM101. Our results support the hypothesis that genes at the critical decision making points in signaling cascades will be enriched for causal variants responsible for phenotypic differences.
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