ArticlePLoS genetics2014
Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- A rapid and dynamic role for FMRP in the plasticity of adult neurons.Nature communications · 2025Article
- Blue light restores functional circadian clocks in eyeless cave spiders.Science advances · 2025Article
- Bmlark is essential for embryonic development.BMC genomics · 2024Article
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- Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity.Frontiers in neuroscience · 2024Article
- RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer.Cancers · 2022Review
- Enteric infection induces Lark-mediated intron retention at the 5' end of Drosophila genes.Genome biology · 2020Article
- Article
- Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates.Nucleic acids research · 2019Article
- Seasonal temperature, the lunar cycle and diurnal rhythms interact in a combinatorial manner to modulate genomic responses to the environment in a reef-building coral.Molecular ecology · 2019Article
- Emerging roles for microRNA in the regulation of Drosophila circadian clock.BMC neuroscience · 2018Review
- What makes ribosomes tick?RNA biology · 2018Review
- Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease.International journal of molecular sciences · 2017Review
- Molecular modulators of the circadian clock: lessons from flies and mice.Cellular and molecular life sciences : CMLS · 2017Review
- Systems Biology-Derived Discoveries of Intrinsic Clocks.Frontiers in neurology · 2017Review
- TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior.Frontiers in molecular neuroscience · 2016Article
- Commentary: A Quest for a Novel Peripheral Biomarker for Narcolepsy.CNS neuroscience & therapeutics · 2015Article
- Comparison of larval and adult Drosophila astrocytes reveals stage-specific gene expression profiles.G3 (Bethesda, Md.) · 2015Article
- The molecular ticks of the Drosophila circadian clock.Current opinion in insect science · 2015Article
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3 authors at 2 institutions in 1 country.
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Abstract
The Drosophila homolog of Casein Kinase I δ/ε, DOUBLETIME (DBT), is required for Wnt, Hedgehog, Fat and Hippo signaling as well as circadian clock function. Extensive studies have established a critical role of DBT in circadian period determination. However, how DBT expression is regulated remains largely unexplored. In this study, we show that translation of dbt transcripts are directly regulated by a rhythmic RNA-binding protein (RBP) called LARK (known as RBM4 in mammals). LARK promotes translation of specific alternative dbt transcripts in clock cells, in particular the dbt-RC transcript. Translation of dbt-RC exhibits circadian changes under free-running conditions, indicative of clock regulation. Translation of a newly identified transcript, dbt-RE, is induced by light in a LARK-dependent manner and oscillates under light/dark conditions. Altered LARK abundance affects circadian period length, and this phenotype can be modified by different dbt alleles. Increased LARK delays nuclear degradation of the PERIOD (PER) clock protein at the beginning of subjective day, consistent with the known role of DBT in PER dynamics. Taken together, these data support the idea that LARK influences circadian period and perhaps responses of the clock to light via the regulated translation of DBT. Our study is the first to investigate translational control of the DBT kinase, revealing its regulation by LARK and a novel role of this RBP in Drosophila circadian period modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.