ArticleJournal of the American Chemical Society2014
Human serotonin receptor 5-HT(1A) preferentially segregates to the liquid disordered phase in synthetic lipid bilayers.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Combining Nanoscale Curvature and Polymer Osmotic Pressure for Efficient Giant Vesicle Assembly Under Physiological Conditions.Small methods · 2025Article
- Osmotic Pressure Enables High-Yield Assembly of Giant Vesicles in Solutions of Physiological Ionic Strengths.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Integration of Data from Liquid-Liquid Phase Separation Databases Highlights Concentration and Dosage Sensitivity of LLPS Drivers.International journal of molecular sciences · 2021Article
- The lipid phase preference of the adenosine AChemical communications (Cambridge, England) · 2019Article
- Photolithographic patterned surface forms size-controlled lipid vesicles.APL bioengineering · 2018Article
- Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes.Soft matter · 2017Article
- Membrane protein reconstitution into giant unilamellar vesicles: a review on current techniques.European biophysics journal : EBJ · 2017Review
- G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition.Biophysical journal · 2016Article
- Compartmentalization and Transport in Synthetic Vesicles.Frontiers in bioengineering and biotechnology · 2016Review
- Evaluating the Raftophilicity of Rhodopsin Photoreceptor in a Patterned Model Membrane.Biophysical journal · 2015Article
- Glucose transport machinery reconstituted in cell models.Chemical communications (Cambridge, England) · 2015Article
- Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.Biochimica et biophysica acta · 2015Article
- Building protein networks in synthetic systems from the bottom-up.Biotechnology advancesReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We demonstrate successful incorporation of the G protein coupled receptor 5-HT1A into giant unilamellar vesicles using an agarose rehydration method. With direct observation using fluorescence techniques, we report preferential segregation of 5-HT1A into the cholesterol-poor liquid disordered phase of the membrane, contradicting previous reports of lipid raft segregation. Furthermore, altering the concentration of cholesterol and sphingomyelin in ternary mixtures does not alter 5-HT1A segregation into the liquid disordered phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.