ArticleJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Risk factors for death in patients with severe asthma.
Article in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Population pharmacokinetic analysis of dupilumab in adult and adolescent patients with asthma.CPT: pharmacometrics & systems pharmacology · 2021Pooled it
- Adverse events of benralizumab in moderate to severe eosinophilic asthma: A meta-analysis.Medicine · 2019Pooled it
- Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity: A Meta-Analysis and Review Under PRISMA Guidelines.Medicine · 2016Pooled it
- SIRT5 Alleviated Eosinophilic Asthma Through ROS Inhibition and Nrf2/HO-1 Activation.Inflammation · 2025Article
- Severe Acute Bronchial Asthma with Sepsis: Determining the Status of Biomarkers in the Diagnosis of the Disease.Diagnostics (Basel, Switzerland) · 2023Review
- Estimating medication adherence from Electronic Health Records: comparing methods for mining and processing asthma treatment prescriptions.BMC medical research methodology · 2023Article
- Real-World Study of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol on Asthma Control in the US.Journal of asthma and allergy · 2023Article
- Determinants of Asthma Attack Among Adult Asthmatic Patients Attending at Public Hospitals of West Shoa Zone, Oromia Regional State, Ethiopia, 2021: Case-Control Study.Journal of asthma and allergy · 2022Article
- Age does not affect the efficacy of anti-IL-5/IL-5R in severe asthmatics.The World Allergy Organization journal · 2019Article
- Future Risks in Patients With Severe Asthma.Allergy, asthma & immunology research · 2019Review
- Predicting asthma attacks in primary care: protocol for developing a machine learning-based prediction model.BMJ open · 2019Article
- Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine?Frontiers in immunology · 2017Review
- Article
- Epidemiological trends of allergic diseases in adolescents.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify risk factors for death among patients with severe asthma.
methodsThis was a nested case-control study. Among the patients with severe asthma treated between December of 2002 and December of 2010 at the Central Referral Outpatient Clinic of the Bahia State Asthma Control Program, in the city of Salvador, Brazil, we selected all those who died, as well as selecting other patients with severe asthma to be used as controls (at a ratio of 1:4). Data were collected from the medical charts of the patients, home visit reports, and death certificates.
resultsWe selected 58 cases of deaths and 232 control cases. Most of the deaths were attributed to respiratory causes and occurred within a health care facility. Advanced age, unemployment, rhinitis, symptoms of gastroesophageal reflux disease, long-standing asthma, and persistent airflow obstruction were common features in both groups. Multivariate analysis showed that male gender, FEV1 pre-bronchodilator < 60% of predicted, and the lack of control of asthma symptoms were significantly and independently associated with mortality in this sample of patients with severe asthma.
conclusionsIn this cohort of outpatients with severe asthma, the deaths occurred predominantly due to respiratory causes and within a health care facility. Lack of asthma control and male gender were risk factors for mortality.
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