ArticlePLoS genetics2014
Hidden diversity in honey bee gut symbionts detected by single-cell genomics.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
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- Integrative Omics and AI-Driven Systems Biology: Multilayer Networks DecodingJournal of proteome research · 2025Review
- scMicrobe PTA: Near Complete Genomes from Single Bacterial Cells.bioRxiv : the preprint server for biology · 2024Article
- scMicrobe PTA: near complete genomes from single bacterial cells.ISME communications · 2024Article
- A phylogenomic and comparative genomic analysis of Commensalibacter, a versatile insect symbiont.Animal microbiome · 2023Article
- Deep Divergence and Genomic Diversification of Gut Symbionts of Neotropical Stingless Bees.mBio · 2023Article
- Review
- Environment or genetic isolation? An atypical intestinal microbiota in the Maltese honey beeFrontiers in microbiology · 2023Article
- Comparative genomics of Lactobacillaceae from the gut of honey bees, Apis mellifera, from the Eastern United States.G3 (Bethesda, Md.) · 2022Article
- Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees.Genome biology and evolution · 2022Article
- Strain-level profiling with picodroplet microfluidic cultivation reveals host-specific adaption of honeybee gut symbionts.Microbiome · 2022Article
- Phylogenomic Analyses ofmSystems · 2022Article
- Genetic divergence and functional convergence of gut bacteria between the Eastern honey beeJournal of advanced research · 2022Article
- Functional characterization of prokaryotic dark matter: the road so far and what lies ahead.Current research in microbial sciences · 2022Review
- High royal jelly production does not impact the gut microbiome of honey bees.Animal microbiome · 2021Article
- A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation.Nature communications · 2021Observational
- BEExact: a Metataxonomic Database Tool for High-Resolution Inference of Bee-Associated Microbial Communities.mSystems · 2021Article
- Cryptic speciation of a pelagic Roseobacter population varying at a few thousand nucleotide sites.The ISME journal · 2020Article
- Characterization of the Kenyan Honey Bee (Microorganisms · 2020Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Microbial communities in animal guts are composed of diverse, specialized bacterial species, but little is known about how gut bacteria diversify to produce genetically and ecologically distinct entities. The gut microbiota of the honey bee, Apis mellifera, presents a useful model, because it consists of a small number of characteristic bacterial species, each showing signs of diversification. Here, we used single-cell genomics to study the variation within two species of the bee gut microbiota: Gilliamella apicola and Snodgrassella alvi. For both species, our analyses revealed extensive variation in intraspecific divergence of protein-coding genes but uniformly high levels of 16S rRNA similarity. In both species, the divergence of 16S rRNA loci appears to have been curtailed by frequent recombination within populations, while other genomic regions have continuously diverged. Furthermore, gene repertoires differ markedly among strains in both species, implying distinct metabolic capabilities. Our results show that, despite minimal divergence at 16S rRNA genes, in situ diversification occurs within gut communities and generates bacterial lineages with distinct ecological niches. Therefore, important dimensions of microbial diversity are not evident from analyses of 16S rRNA, and single cell genomics has potential to elucidate processes of bacterial diversification.
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