ArticleTropical life sciences research2014
Antihyperglycaemic and Toxicological Evaluations of Extract and Fractions of Gynura procumbens Leaves.
Article in Tropical life sciences research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Extracts, Fractions, and Subfractions from Purple-Orange Sweet Potato (Molecules (Basel, Switzerland) · 2025Article
- Antidiabetic potential ofFrontiers in pharmacology · 2025Review
- Anti-cancer effects ofOpen veterinary journal · 2024Article
- Potentials of Gynura procumbens to modulate chronic stress and immunological responses in Oreochromis niloticus.PloS one · 2023Article
- Antifungal Activity and Plant Growth-Promoting Properties ofMicroorganisms · 2022Article
- In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Antioxidant and Anti-Inflammatory Effects of GenusFrontiers in pharmacology · 2020Article
- Production of biomass and flavonoid ofJournal, genetic engineering & biotechnology · 2018Article
- Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component.BMC complementary and alternative medicine · 2017Article
- Gynura procumbens: An Overview of the Biological Activities.Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acute and sub-chronic antihyperglycaemic activity, safety margin evaluations and chemical composition of ethanol extract (EE) and fractions of Gynura procumbens (GP) were studied. Streptozotocin (STZ)-induced diabetic rats (SDRs) and the Organisation for Economic Cooperation and Development (OECD) guidelines 425 and 407 were used in the antidiabetic and toxicity studies, respectively. Biochemical and haematological data obtained from both acute and sub-chronic procedures suggest that the extract is safe at the limit test dose (2000 mg/kg); thus, the oral lethal dose (LD50) exceeds 2000 mg/kg. The acceptable daily intake (ADI) was determined to be 700 mg/kg/day. In the acute antihyperglycaemic study, the n-butanol fraction (n-BF) was found to consistently lower glucose levels the most effectively, which was also demonstrated in the 14-day study. Not only did the n-BF show the highest dose-dependent glucose-lowering action (51.2% and 62.0% at 500 mg/kg and 1000 mg/kg, respectively), its effect was the closest to that of metformin (63.6%, p<0.05). The estimated amount of flavonoids in n-BF were 62.90% and 79.68% higher than the ethyl acetate fraction (EAF) and aqueous fraction (AF), respectively (p<0.05), with a corresponding value of 61.22% and 49.33% for phenolics (p<0.05). GP leaves have a no-observed-adverse-effect-level (NOAEL) and antihyperglycaemic activity corresponding to the high content of phenols and flavonoids. Therefore, GP leaves are a promising source of new antidiabetic natural products.
Indexed as
Identifiers
25210589PMC4156475W2182952896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.