Evidence map›Paper›PMID 25210551›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2014

Endogenous biotin expression in renal and testicular tumours and literature review.

Nader Fahmy, Mark Woo, Mona Alameldin, Joe King Lee, Kyle MacDonald, Lee W Goneau, Peter Cadieux, Jeremy Burton, Stephen Pautler

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Nader FahmyDivision of Urology, Department of Surgery, Western University, London ON;
Mark WooDivision of Urology, Department of Surgery, Western University, London ON;
Mona AlameldinDepartment of Anatomical Pathology, Western University, London ON;
Joe King LeeDivision of Urology, Department of Surgery, Western University, London ON;
Kyle MacDonaldDepartment of Microbiology and Immunology, Western University, London ON;
Lee W GoneauDepartment of Microbiology and Immunology, Western University, London ON;
Peter CadieuxDepartment of Microbiology and Immunology, Western University, London ON;
Jeremy BurtonDivision of Urology, Department of Surgery, Western University, London ON; ; Department of Microbiology and Immunology, Western University, London ON;
Stephen PautlerDivision of Urology, Department of Surgery, Western University, London ON; ; Division of Surgical Oncology, Department of Oncology, Western University, London ON.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to examine endogenous biotin levels in tumour specimens collected from patients with renal and testicular tumours and compare them to the surrounding non-neoplastic surgical margin.

methodsFrozen samples were obtained from the Ontario Tumour Bank. Renal and testicular tumour tissue were included in this study. Normal tissue from the negative surgical margins of each tumour served as a control. Biotin detection in tissue specimens was determined using immunohistochemistry (IHC).

resultsSpecimens collected from 56 patients (36 men and 20 women) were included in this study. Histopathology of the 52 renal tumours included 31 (60%) conventional type RCC, 5 (10%) chromophobe RCC, 5 (10%) papillary RCC, 1 (2%) oncocytoma and 10 (19%) upper tract urothelial carcinoma (UC). The 4 testicular tumours included 1 seminomatous (25%) germ cell tumour and 3 (75%) non seminomatous germ cell tumours.

conclusionNo biotin signal was perceived in all tested tumour samples. Endogenous biotin expression was detected in the matching non-neoplastic surgical margin of tested renal tissues. This lack of staining may prove to be a valuable tool in future studies.

Identifiers

PMID25210551
PMCPMC4137012
OpenAlexW2127679368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.